公开(公告)号：US20210270765A1

公开(公告)日：2021-09-02

申请号：US17186675

申请日：2021-02-26

申请人： Korea University Research and Business Foundation

发明人： Hee-Min KANG ,  Chandra KHATUA ,  Gun-Hyu BAE ,  Hyo-Jun CHOI ,  Sun-Hong MIN

IPC分类号： G01N27/327 ,  C07K14/705

摘要： The present invention relates to a nano-ligand for promoting cell adhesion and differentiation of stem cells and a method of promoting cell adhesion and differentiation of stem cells by using the nano-ligand, and the method of promoting cell adhesion and differentiation of stem cells according to the present invention may temporally and spatially, and reversibly control nano-ligand sliding by applying a magnetic field to a substrate including the nano-ligands, and efficiently control stem cell adhesion and differentiation ex vivo or in vivo through the magnetic-field based on spatiotemporal control.

公开(公告)号：US20210269773A1

公开(公告)日：2021-09-02

申请号：US17186723

申请日：2021-02-26

申请人： Korea University Research and Business Foundation

发明人： Hee-Min KANG ,  Chandra KHATUA ,  Gun-Hyu BAE ,  Hyo-Jun CHOI ,  Sun-Hong MIN

IPC分类号： C12N5/0786 ,  A61K9/51 ,  C12N13/00

摘要： The present invention relates to a nano-ligand for promoting cell adhesion and regeneration of macrophages and a method of promoting cell adhesion and regeneration of macrophages by using the nano-ligand. The method of promoting cell adhesion and regeneration of macrophages according to the present invention applies a magnetic field to a substrate including the nano-ligand, so that it is possible to reversely control the sliding of the nano-ligand, as well as temporally and spatially control the sliding of the nano-ligand, and efficiently control cell adhesion and phenotypic polarization of macrophages in vivo or ex vivo through the magnetic field-based spatiotemporal control.