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1.发明公开公开(公告)号：US20230210992A1
公开(公告)日：2023-07-06
申请号：US17836403
申请日：2022-06-09
发明人： Young-Keun KIM , Heemin KANG , THOMAS MYEONGSEOK KOO , Myeong-Soo KIM , Sung-Gue LEE , Gun-Hyu BAE
IPC分类号： A61K41/00 , C12N13/00 , C12N5/0775 , A61N2/00
CPC分类号： A61K41/00 , C12N13/00 , C12N5/0662 , A61N2/004
摘要： The present invention relates to a nanosatellite-substrate complex capable of regulating stem cell adhesion and differentiation, and a method for preparing the same. Moreover, the present invention relates to a method of regulating stem cell adhesion and differentiation by applying a magnetic field to the nanosatellite-substrate complex.
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2.发明公开公开(公告)号：US20230149605A1
公开(公告)日：2023-05-18
申请号：US17963601
申请日：2022-10-11
申请人： Korea University Research and Business Foundation , Industry-University Cooperation Foundation Hanyang University ERICA Campus
发明人： Heemin KANG , Do-Kyoon KIM , Yu-Ri KIM , Gun-Hyu BAE
CPC分类号： A61L31/047 , A61L31/022 , A61L31/10 , A61L2400/12 , A61L2300/40
摘要： The present invention relates to a nanobarrier for regulating macrophage adhesion and polarization. Moreover, the present invention relates to a method of regulating macrophage adhesion and polarization using the nanobarrier. According to the nanobarrier of the present invention and the method of regulating macrophage adhesion and polarization using the same, it is possible to efficiently regulate macrophage adhesion and polarization by applying a magnetic field to the nanobarrier.
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公开(公告)号：US20230330232A1
公开(公告)日：2023-10-19
申请号：US17989940
申请日：2022-11-18
发明人： Heemin KANG , Yu-Ri KIM , Gun-Hyu BAE , Sung-Gue LEE , Na-Yeon KANG , Sun-Hong MIN , Seong-Yeol KIM
CPC分类号： A61K47/02 , A61K9/0009 , A61K45/06
摘要： Disclosed is a self-assembled complex containing an iron ion that includes an iron ion; and at least one ligand, where the iron ion and the ligand are reversibly self-assembled or self-disassembled. The iron ion and the ligand are self-assembled to form an assembly structure at least part of which is round shaped.
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公开(公告)号：US20230330005A1
公开(公告)日：2023-10-19
申请号：US17989930
申请日：2022-11-18
发明人： Heemin KANG , Sung-Gue LEE , Na-Yeon KANG , Yu-Ri KIM , Gun-Hyu BAE , Da-Hee KIM , Seong-Yeol KIM
CPC分类号： A61K9/0002 , A61K45/06
摘要： Disclosed is a self-assembled complex containing a calcium ion that includes a calcium ion; and at least one ligand, where the calcium ion and the ligand participate in a reversibly self-assembly or self-disassembly. The shape of the self-assembled complex varies depending on the type of the ligand, or the mixing ratio of the ligand when there are a plurality of ligands.
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公开(公告)号：US20210270765A1
公开(公告)日：2021-09-02
申请号：US17186675
申请日：2021-02-26
发明人： Hee-Min KANG , Chandra KHATUA , Gun-Hyu BAE , Hyo-Jun CHOI , Sun-Hong MIN
IPC分类号： G01N27/327 , C07K14/705
摘要： The present invention relates to a nano-ligand for promoting cell adhesion and differentiation of stem cells and a method of promoting cell adhesion and differentiation of stem cells by using the nano-ligand, and the method of promoting cell adhesion and differentiation of stem cells according to the present invention may temporally and spatially, and reversibly control nano-ligand sliding by applying a magnetic field to a substrate including the nano-ligands, and efficiently control stem cell adhesion and differentiation ex vivo or in vivo through the magnetic-field based on spatiotemporal control.
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公开(公告)号：US20210269773A1
公开(公告)日：2021-09-02
申请号：US17186723
申请日：2021-02-26
发明人： Hee-Min KANG , Chandra KHATUA , Gun-Hyu BAE , Hyo-Jun CHOI , Sun-Hong MIN
IPC分类号： C12N5/0786 , A61K9/51 , C12N13/00
摘要： The present invention relates to a nano-ligand for promoting cell adhesion and regeneration of macrophages and a method of promoting cell adhesion and regeneration of macrophages by using the nano-ligand. The method of promoting cell adhesion and regeneration of macrophages according to the present invention applies a magnetic field to a substrate including the nano-ligand, so that it is possible to reversely control the sliding of the nano-ligand, as well as temporally and spatially control the sliding of the nano-ligand, and efficiently control cell adhesion and phenotypic polarization of macrophages in vivo or ex vivo through the magnetic field-based spatiotemporal control.
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