公开(公告)号：US20230404909A1

公开(公告)日：2023-12-21

申请号：US18154566

申请日：2023-01-13

Applicant: LEO Pharma A/S

Inventor： Karsten PETERSSON ,  Karen Margrethe ENGELL ,  Jorgen JANSSON ,  Kim Troensegaard NIELSEN ,  Andre Huss ERIKSSON ,  Anne MOORE ,  Sonja VUCEN ,  Caroline O'SULLIVAN ,  Abina CREAN

IPC: A61K9/00 ,  A61K31/573 ,  A61K31/593 ,  A61K31/59 ,  A61K47/32 ,  A61K47/34 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K31/573 ,  A61K31/593 ,  A61K31/59 ,  A61K47/32 ,  A61K47/34 ,  A61M37/0015 ,  A61M2037/0053 ,  A61M2037/0046 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: The present invention relates to a microneedle patch composition comprising one or more microneedles each comprising: (a) a tapered tip portion containing a therapeutically active ingredient dispersed in a matrix of a biodegradable polymer capable of providing sustained release of the therapeutically active ingredient over a period of at least two days after insertion of the microneedle or microneedles into the skin, and (b) a fast dissolving microneedle backing layer portion containing a water-soluble polymer overlayering the tip portion, said microneedle or microneedles being attached to and extending from an adhesive surface of a removable substrate.