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    Topical Compositions Comprising Fipronil and Permethrin and Methods of Use
    2.
    发明申请
    Topical Compositions Comprising Fipronil and Permethrin and Methods of Use 审中-公开
    包含氟虫腈和苄氯菊酯的主题组合物和使用方法

    公开(公告)号：US20160361297A1

    公开(公告)日：2016-12-15

    申请号：US15248327

    申请日：2016-08-26

    Applicant: MERIAL, INC.

    Inventor： Mark David Soll ,  James Pate ,  Lisa A. Baker

    IPC: A61K31/415 ,  A61K9/00 ,  A61K31/4402 ,  A61K31/201 ,  A61K47/44 ,  A01N25/02 ,  A61K47/10 ,  A61K45/06 ,  A01N49/00 ,  A01N43/40 ,  A01N37/38 ,  A01N43/56 ,  A61K31/216 ,  A61K47/22

    CPC classification number: A61K31/415 ,  A01N25/02 ,  A01N25/22 ,  A01N37/38 ,  A01N43/40 ,  A01N43/56 ,  A01N47/02 ,  A01N49/00 ,  A01N53/00 ,  A61K9/0017 ,  A61K31/201 ,  A61K31/215 ,  A61K31/216 ,  A61K31/4402 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/44 ,  A61K2300/00 ,  A01N2300/00

    Abstract: The subject matter disclosed herein is directed to stable, highly-effective topical formulations comprising permethrin, fipronil and a solvent system that is sufficient to solubilize these two active ingredients and limit degradation of fipronil to its sulfone, and their uses in topical applications on animals and the environment. Useful formulations comprise from about 30% to about 55% (w/w) permethrin and about 2 to 15% (w/w) fipronil and a solvent system that comprises N-methyl pyrrolidone and a glycol, glycol ether, glycol ester, fatty acid ester or neutral oil, wherein the N-methyl pyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight: weight ratio of from about 1:2.0 to about 1:3.5, glycol, glycol ether, glycol ester, fatty acid ester or neutral oil to n-methyl pyrrolidone. These two actives when combined in the described amounts have been found to have unexpected enhanced repellent activity against stable fly. However, it is the formulations described herein that provide solvency and stability that maintain synergistic concentrations after application on an animal.

    Abstract translation: 本文公开的主题涉及稳定的，高效的局部制剂，其包含氯菊酯，氟虫腈和溶剂体系，其足以溶解这两种活性成分并限制氟虫腈对其砜的降解，以及它们在局部应用于动物和 环境。 有用的制剂包含约30％至约55％（w / w）苄氯菊酯和约2至15％（w / w）氟虫腈和包含N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪 酸酯或中性油，其中N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪酸酯或中性油以重量比为约1:2.0至约1:3.5存在，乙二醇，乙二醇 醚，乙二醇酯，脂肪酸酯或中性油加到正甲基吡咯烷酮中。 已经发现当以所述量组合时，这两种活性物质具有针对稳定蝇的意想不到的增强的驱避活性。 然而，本文所述的制剂提供了在施用于动物之后保持协同浓度的溶解能力和稳定性。

    Topical delivery formulation
    7.
    发明授权
    Topical delivery formulation 有权

    公开(公告)号：US09756852B2

    公开(公告)日：2017-09-12

    申请号：US14600651

    申请日：2015-01-20

    Applicant: MERIAL INC.

    Inventor： James Pate ,  Natalya Shub

    IPC: A01N25/34 ,  A01N25/10 ,  A01N43/56 ,  A01N53/00 ,  A61K9/00

    CPC classification number: A01N25/10 ,  A01N43/56 ,  A01N53/00 ,  A61K9/0014

    Abstract: The invention is a pour-on antiparasitic formulation having superior water resistant properties. The pour-on formulation utilizes one or more polymers (water insoluble with or without water soluble) in the range of about 5 to about 40% w/w, one or more solvents in the range of about 50 to about 94% w/w, with or without additive (e.g., isopropanol or ethanol) in the range of about 5 to about 30% w/w, and optionally a plasticizer in the range of about 0.5 to about 25% w/w. The pour-on antiparasitic formulation features limited spreading when applied to animals (cattle, sheep, dogs and the like). The pour-on antiparasitic formulation further partially evaporates, leaving a water resistant polymer matrix that diffuses at least one active ingredient to the animal's skin.

    TOPICAL DELIVERY FORMULATION
    8.
    发明申请
    TOPICAL DELIVERY FORMULATION 有权
    主题交付配方

    公开(公告)号：US20150201611A1

    公开(公告)日：2015-07-23

    申请号：US14600651

    申请日：2015-01-20

    Applicant: MERIAL INC.

    Inventor： James Pate ,  Natalya Shub

    IPC: A01N25/10 ,  A01N53/00 ,  A01N43/56

    CPC classification number: A01N25/10 ,  A01N43/56 ,  A01N53/00 ,  A61K9/0014

    Abstract: The invention is a pour-on antiparasitic formulation having superior water resistant properties. The pour-on formulation utilizes one or more polymers (water insoluble with or without water soluble) in the range of about 5 to about 40% w/w, one or more solvents in the range of about 50 to about 94% w/w, with or without additive (e.g., isopropanol or ethanol) in the range of about 5 to about 30% w/w, and optionally a plasticizer in the range of about 0.5 to about 25% w/w. The pour-on antiparasitic formulation features limited spreading when applied to animals (cattle, sheep, dogs and the like). The pour-on antiparasitic formulation further partially evaporates, leaving a water resistant polymer matrix that diffuses at least one active ingredient to the animal's skin.

    Abstract translation: 本发明是具有优异防水性能的浇注抗寄生虫制剂。 倾注配方使用一种或多种聚合物（水溶性或不含水溶性）在约5至约40％w / w的范围内，一种或多种在约50至约94％w / w范围内的溶剂 ，含或不含有约5至约30％w / w范围内的添加剂（例如异丙醇或乙醇），以及任选的增塑剂在约0.5至约25％w / w范围内。 灌注抗寄生虫制剂在施用于动物（牛，绵羊，狗等）时具有有限的扩散。 浇注抗寄生虫制剂进一步部分蒸发，留下将至少一种活性成分扩散至动物皮肤的防水聚合物基质。

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