公开(公告)号：US10857121B2

公开(公告)日：2020-12-08

申请号：US15304018

申请日：2015-04-17

Applicant: MERIAL INC. ,  BASF, SE

Inventor： Charles Meng ,  Christian Miculka ,  Mark Soll ,  Ralph Paulini ,  Matthias Pohlman ,  Sebastian Sorgel ,  Henricus Maria Martinus Bastiaans ,  Sarah Rachel Devereux ,  Cecille Ebuenga Doyog ,  Anna Malveda Umali ,  Rhoel Suiza Cosare ,  Christopher Palmer ,  Takeo Hokama

IPC: A61K31/277 ,  A01N37/34 ,  A01K11/00 ,  A61D7/00 ,  A61K9/00 ,  A61K31/357

Abstract: The present invention provides uses of aryl alkyl malononitrile compounds of formula (I), or veterinarily acceptable salts thereof, for controlling and preventing parasite infestations in animals. The invention also provides methods for controlling and preventing parasite infestation in animals comprising administering an effective amount of at least one aryl alkyl malononitrile compound of formulae (I), or a veterinarily acceptable salt thereof, to the animal.

公开(公告)号：US20180362589A1

公开(公告)日：2018-12-20

申请号：US16111027

申请日：2018-08-23

Applicant: MERIAL INC.

Inventor： Loic Le Hir de Fallois ,  Greg Pacofsky ,  Alan Long ,  Charles Meng ,  Hyoung Ik Lee ,  Cyprian O. Ogbu

IPC: C07K11/02 ,  C07D273/00

Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

公开(公告)号：US10081656B2

公开(公告)日：2018-09-25

申请号：US15160577

申请日：2016-05-20

Applicant: MERIAL INC.

Inventor： Loic Le Hir de Fallois ,  Greg Pacofsky ,  Alan Long ,  Charles Meng ,  Hyoung Ik Lee ,  Cyprian O. Ogbu

IPC: A61P33/00 ,  C07K11/02 ,  A01N43/72 ,  C07D273/00 ,  A61K38/00

CPC classification number: C07K11/02 ,  A01N43/72 ,  A61K38/00 ,  C07D273/00 ,  A01N37/46 ,  A01N43/90

Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

公开(公告)号：US20170290803A1

公开(公告)日：2017-10-12

申请号：US15632705

申请日：2017-06-26

Applicant: MERIAL, INC.

Inventor： Charles Meng ,  Loïc Le Hir de Fallois

IPC: A61K31/404 ,  C07D209/10 ,  C07D401/04 ,  C07D209/08

CPC classification number: A61K31/404 ,  C07D209/08 ,  C07D209/10 ,  C07D401/04 ,  C07D401/12 ,  H03K5/04 ,  H03K7/00

Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

公开(公告)号：US10251863B2

公开(公告)日：2019-04-09

申请号：US15632705

申请日：2017-06-26

Applicant: MERIAL, INC.

Inventor： Charles Meng ,  Loïc Le Hir de Fallois

IPC: C07D209/08 ,  A61K31/404 ,  C07D209/10 ,  C07D401/04 ,  C07D401/12 ,  H03K5/04 ,  H03K7/00

Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

公开(公告)号：US09776986B2

公开(公告)日：2017-10-03

申请号：US14744166

申请日：2015-06-19

Applicant: MERIAL, INC.

Inventor： Charles Meng ,  Loïc Le Hir de Fallois

IPC: C07D209/08 ,  C07D401/12 ,  C07D209/10 ,  C07D401/04 ,  H03K5/04 ,  H03K7/00

CPC classification number: A61K31/404 ,  C07D209/08 ,  C07D209/10 ,  C07D401/04 ,  C07D401/12 ,  H03K5/04 ,  H03K7/00

Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

公开(公告)号：US20170027899A1

公开(公告)日：2017-02-02

申请号：US15304018

申请日：2015-04-17

Applicant: MERIAL INC. ,  BASF, SE

Inventor： Charles Meng ,  Christian Miculka ,  Mark Soll ,  Ralph Paulini ,  Matthias Pohlman ,  Sebastian Sorgel ,  Henricus Maria Martinus Bastiaans ,  Sarah Thompson ,  Cecille Ebuenga Doyog ,  Anna Malveda Umali ,  Rhoel Suiza Cosare ,  Christopher Palmer ,  Takeo Hokama

IPC: A61K31/277 ,  A61D7/00 ,  A01K11/00 ,  A61K9/00 ,  A61K31/357

Abstract: The present invention provides uses of aryl alkyl malononitrile compounds of formula (I), or veterinarily acceptable salts thereof, for controlling and preventing parasite infestations in animals. The invention also provides methods for controlling and preventing parasite infestation in animals comprising administering an effective amount of at least one aryl alkyl malononitrile compound of formulae (I), or a veterinarily acceptable salt thereof, to the animal.

Abstract translation: 本发明提供式（I）的芳基烷基丙二腈化合物或其兽医学上可接受的盐用于控制和预防动物中的寄生虫感染的用途。 本发明还提供了用于控制和预防动物中寄生虫侵袭的方法，包括向动物施用有效量的至少一种式（I）的芳基烷基丙二腈化合物或其兽医学上可接受的盐。

公开(公告)号：US20170022253A1

公开(公告)日：2017-01-26

申请号：US15160577

申请日：2016-05-20

Applicant: MERIAL INC.

Inventor： Loic Le Hir de Fallois ,  Greg Pacofsky ,  Alan Long ,  Charles Meng ,  Hyoung Ik Lee ,  Cyprian O. Ogbu

IPC: C07K11/02

CPC classification number: C07K11/02 ,  A01N43/72 ,  A61K38/00 ,  C07D273/00 ,  A01N37/46 ,  A01N43/90

Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

Abstract translation: 本发明提供式（I）的环状缩肽化合物和包含有效对抗伤害动物的寄生虫的化合物的组合物。 化合物和组合物可用于对抗哺乳动物和鸟类中或哺乳动物上的寄生虫。 本发明还提供了用于消除，控制和预防鸟类和哺乳动物中的寄生虫感染的改进方法。

公开(公告)号：US20150366198A1

公开(公告)日：2015-12-24

申请号：US14744166

申请日：2015-06-19

Applicant: MERIAL, INC.

Inventor： Charles Meng ,  Loïc Le Hir de Fallois

IPC: A01N43/38 ,  C07D209/10 ,  A01N37/34 ,  C07D209/08 ,  C07D401/12 ,  A01N43/40 ,  C07D401/04

CPC classification number: A61K31/404 ,  C07D209/08 ,  C07D209/10 ,  C07D401/04 ,  C07D401/12 ,  H03K5/04 ,  H03K7/00

Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

Abstract translation: 本发明涉及用于对抗哺乳动物中的肝吸虫寄生虫的口服，局部或可注射的组合物，其包含至少一种吲哚衍生物活性剂。 本发明还提供了用于消除和控制哺乳动物的肝吸虫寄生虫感染和侵染的改进方法，包括将本发明的组合物给予有需要的哺乳动物。