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公开(公告)号：US20160185726A1
公开(公告)日：2016-06-30
申请号：US14981847
申请日：2015-12-28
申请人： MERIAL, INC.
发明人： Charles Q. Meng , Alan Long , Scot Huber , Srinivas Reddy Gurrala , Douglas Edward Wilkinson , Gregory Pacofsky
IPC分类号： C07D215/38 , A61K31/495 , A61K31/496 , C07D307/81 , C07C233/56 , A61K31/167 , C07D401/12 , C07D263/58 , C07D211/58 , C07D277/64 , C07D277/82 , C07D471/08 , C07D213/74 , C07D333/66 , C07D333/60 , A61K31/47 , A61K31/4995 , A61K31/472 , C07D295/16
CPC分类号： C07D215/38 , A61K31/167 , A61K31/47 , A61K31/4704 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07C233/56 , C07C235/16 , C07C2601/14 , C07D211/58 , C07D213/74 , C07D215/42 , C07D217/06 , C07D241/04 , C07D263/58 , C07D277/64 , C07D277/82 , C07D295/15 , C07D295/16 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/81 , C07D307/82 , C07D333/60 , C07D333/66 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/08 , Y02A50/423
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
摘要翻译： 本发明涉及以下式（I）的新型驱肠剂化合物：其中Y和Z独立地为双环碳环或双环杂环基，或Y或Z中的一个为双环碳环或双环杂环基，Y中的另一个为 或Z是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，变量X1，X2，X3，X4，X5，X6，X7和X8如本文所定义。 本发明还提供包含本发明的驱肠剂化合物的兽用组合物及其用于治疗和预防动物寄生虫感染的用途。
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公开(公告)号：US09249102B2
公开(公告)日：2016-02-02
申请号：US14083879
申请日：2013-11-19
申请人： MERIAL INC.
IPC分类号： A61K31/497 , C07D401/00 , C07D215/38 , A61K31/167 , A61K31/4704 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07D241/04 , C07D277/64 , C07D307/81 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/08 , C07D403/12 , C07D213/74 , C07D215/42 , C07D217/06 , C07D333/66 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D263/58 , C07D277/82 , C07D295/15 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/82 , C07C233/56 , C07C235/16
CPC分类号： C07D215/38 , A61K31/167 , A61K31/47 , A61K31/4704 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K45/06 , C07C233/56 , C07C235/16 , C07C2601/14 , C07D211/58 , C07D213/74 , C07D215/42 , C07D217/06 , C07D241/04 , C07D263/58 , C07D277/64 , C07D277/82 , C07D295/15 , C07D295/16 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/81 , C07D307/82 , C07D333/60 , C07D333/66 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/08
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
摘要翻译： 本发明涉及以下式（I）的新型驱肠剂化合物：其中Y和Z独立地为双环碳环或双环杂环基，或Y或Z中的一个为双环碳环或双环杂环基，Y中的另一个为 或Z是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，变量X1，X2，X3，X4，X5，X6，X7和X8如本文所定义。 本发明还提供包含本发明的驱肠剂化合物的兽用组合物及其用于治疗和预防动物寄生虫感染的用途。
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公开(公告)号：US10463661B2
公开(公告)日：2019-11-05
申请号：US16054101
申请日：2018-08-03
申请人： MERIAL INC.
发明人： Alan Long , Srinivas Reddy Gurrala
IPC分类号： A61K31/496 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/06 , H05B41/06 , A61K31/06 , A61K31/423 , A61K31/4468 , A61K31/454 , A61K31/495 , A61K45/06
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W′, R2, R3, R, R′, m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
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公开(公告)号：US20190133129A1
公开(公告)日：2019-05-09
申请号：US16182838
申请日：2018-11-07
申请人： MERIAL INC.
发明人： Chunhua Yang , Loic Patrick Le Hir de Fallois , Charles Q. Meng , Alan Long , Roelof Johannes Gorter de Vries , Bruno Baillon , Sylvaine Lafont , Myriam Gay de Saint Michel , Stephane Kozlovic
IPC分类号： A01N43/80 , C07D261/04 , A01N43/42 , A61K31/42 , C07D453/04
摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
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公开(公告)号：US20180362589A1
公开(公告)日：2018-12-20
申请号：US16111027
申请日：2018-08-23
申请人： MERIAL INC.
发明人： Loic Le Hir de Fallois , Greg Pacofsky , Alan Long , Charles Meng , Hyoung Ik Lee , Cyprian O. Ogbu
IPC分类号： C07K11/02 , C07D273/00
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
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公开(公告)号：US20180338972A1
公开(公告)日：2018-11-29
申请号：US16054101
申请日：2018-08-03
申请人： MERIAL INC.
发明人： Alan Long , Srinivas Reddy Gurrala
IPC分类号： A61K31/496 , A61K45/06 , A61K31/495 , A61K31/454 , A61K31/4468 , A61K31/423 , C07D413/04 , H05B41/06 , C07D487/06 , C07D417/14 , C07D417/12 , C07D417/04 , A61K31/06
CPC分类号： A61K31/496 , A61K31/06 , A61K31/423 , A61K31/4468 , A61K31/454 , A61K31/495 , A61K45/06 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/06 , H05B41/06
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W′, R2, R3, R, R′, m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
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公开(公告)号：US10081656B2
公开(公告)日：2018-09-25
申请号：US15160577
申请日：2016-05-20
申请人： MERIAL INC.
发明人： Loic Le Hir de Fallois , Greg Pacofsky , Alan Long , Charles Meng , Hyoung Ik Lee , Cyprian O. Ogbu
IPC分类号： A61P33/00 , C07K11/02 , A01N43/72 , C07D273/00 , A61K38/00
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
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公开(公告)号：US10045979B2
公开(公告)日：2018-08-14
申请号：US15311848
申请日：2015-05-19
申请人： MERIAL INC.
发明人： Alan Long , Srinivas Reddy Gurrala
IPC分类号： A61K31/496 , A61K31/4468 , A61K31/495 , A61K45/06 , A61K31/06 , A61K31/423 , A61K31/454
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W′, R2, R3, R, R′, m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
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公开(公告)号：US20170100394A1
公开(公告)日：2017-04-13
申请号：US15311848
申请日：2015-05-19
申请人： MERIAL INC.
发明人： Alan Long , Srinivas Reddy Gurrala
IPC分类号： A61K31/496 , A61K31/495 , A61K31/454 , A61K31/06 , A61K31/423 , A61K31/4468 , A61K45/06
CPC分类号： A61K31/496 , A61K31/06 , A61K31/423 , A61K31/4468 , A61K31/454 , A61K31/495 , A61K45/06 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/06 , H05B41/06
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W′, R2, R3, R, R′, m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
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公开(公告)号：US20170311601A1
公开(公告)日：2017-11-02
申请号：US15480316
申请日：2017-04-05
申请人： MERIAL INC.
发明人： Chunhua Yang , Loic Patrick Le Hir de Fallois , Charles Q. Meng , Alan Long , Roelof Johannes Gorter de Vries , Bruno Baillon , Sylvaine Lafont , Myriam Gay de Saint Michel , Stephane Kozlovic
IPC分类号： A01N43/80 , A01N43/42 , A61K31/42 , C07D261/04
CPC分类号： A01N43/80 , A01N43/42 , A61K31/42 , C07D261/04 , C07D453/04
摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
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