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公开(公告)号：US20220119344A1
公开(公告)日：2022-04-21
申请号：US16956871
申请日：2020-06-04
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor： Patrick M. WOSTER , Joy E. KIRKPATRICK
IPC: C07C235/38
Abstract: The invention relates to KDM4B inhibitors, compositions comprising an effective amount of KDM4B inhibitors and methods for treating inflammatory diseases and disorders.
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2.发明申请公开(公告)号：US20150065434A1
公开(公告)日：2015-03-05
申请号：US14473305
申请日：2014-08-29
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor： Patrick M. WOSTER , Isuru R. KUMARASINGHE
IPC: C07K14/00
CPC classification number: A61K38/1709
Abstract: Provided herein are cyclic peptide inhibitors of lysine-specific demethylase 1. These cyclic peptides have the potential to treat cancer, diabetes, cardiovascular disease, and neurological disorders.
Abstract translation: 本文提供赖氨酸特异性脱甲基酶1的环肽抑制剂。这些环肽具有治疗癌症，糖尿病，心血管疾病和神经障碍的潜力。
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公开(公告)号：US20230101743A1
公开(公告)日：2023-03-30
申请号：US17790798
申请日：2021-01-06
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor： Stephen DUNCAN , Juitung LIU , Patrick M. WOSTER , Yuri PETERSON , Steven HOLSHOUSER , Yu-Lin JIANG
IPC: C07D251/40 , C07D403/14 , C07D403/04
Abstract: The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, hypercholesterolemia.
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4.发明申请AMINOTRIAZOLE- AND AMINOTETRAZOLE-BASED KDM1A INHIBITORS AS EPIGENETIC MODULATORS 审中-公开氨基腈和氨基三唑基KDM1A抑制剂作为调节剂公开(公告)号：US20170001968A1
公开(公告)日：2017-01-05
申请号：US15115342
申请日：2015-02-06
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor： Patrick M. WOSTER , Craig J. KUTZ
IPC: C07D249/14 , C07D405/12 , C07D403/12 , C07D257/06
CPC classification number: C07D249/14 , C07D257/06 , C07D403/12 , C07D405/12
Abstract: In some aspects, the present invention provides compounds of the formula (IV), wherein the variables are as defined herein, which may be used as inhibitors of histone demethylase or spermine oxidase. Also provided herein are pharmaceutical compositions of the compounds and methods using the compounds in the treatment of diseases such as cancer and cardiovascular disease.
Abstract translation: 在一些方面，本发明提供式（IV）化合物，其中变量如本文所定义，其可用作组蛋白脱甲基酶或精胺氧化酶的抑制剂。 本文还提供了化合物的药物组合物和使用该化合物治疗诸如癌症和心血管疾病的疾病的方法。
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