公开(公告)号：US07101699B2

公开(公告)日：2006-09-05

申请号：US10381471

申请日：2001-09-26

申请人： Makoto Ito ,  Masako Furusato ,  Noriyuki Sueyoshi

发明人： Makoto Ito ,  Masako Furusato ,  Noriyuki Sueyoshi

IPC分类号： C12N9/80 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC分类号： C07K16/40 ,  A61K38/00 ,  C12N9/80

摘要： A polypeptide possessing a sphingolipid ceramide deacylase activity; a nucleic acid encoding the polypeptide; a recombinant DNA comprising the nucleic acid; a carrier for introducing into a cell, carrying the nucleic acid or the recombinant DNA; a transformant harboring the nucleic acid or the recombinant DNA; an oligonucleotide probe or primer for the nucleic acid; a method for detecting the nucleic acid using the probe or the primer and a kit usable therefor; an antibody or a fragment thereof against the polypeptide; and a method for detecting the polypeptide using the antibody or a fragment thereof and a kit usable therefor. According to the present invention, there can be applied to engineering of sphingolipids, and to treatments for diseases such as diseases of nervous system (for instance, neurodegenerative diseases and the like), leukemia and wounds.

摘要翻译： 具有神经鞘脂神经酰胺脱酰酶活性的多肽; 编码该多肽的核酸; 包含该核酸的重组DNA; 用于引入细胞携带核酸或重组DNA的载体; 携带核酸或重组DNA的转化体; 用于核酸的寡核苷酸探针或引物; 使用探针或引物检测核酸的方法和可用于其的试剂盒; 针对多肽的抗体或其片段; 以及使用抗体或其片段检测多肽的方法和可用于其的试剂盒。 根据本发明，可以应用鞘脂的工程化，神经系统疾病（例如神经变性疾病等），白血病和伤口等疾病的治疗。