公开(公告)号：US09125959B1

公开(公告)日：2015-09-08

申请号：US14056186

申请日：2013-10-17

申请人： Mark Lawrence Kayton ,  Norma Alcantar ,  Daniel Restrepo ,  Nicholas S. Laconi ,  Audrey Lynn Buttice ,  Michael Pierce Ebaugh

发明人： Mark Lawrence Kayton ,  Norma Alcantar ,  Daniel Restrepo ,  Nicholas S. Laconi ,  Audrey Lynn Buttice ,  Michael Pierce Ebaugh

IPC分类号： A61L2/18 ,  A01N65/08

CPC分类号： A61L2/18 ,  A01N31/02 ,  A01N65/08 ,  A61L29/005 ,  A61L29/06 ,  A61L29/08 ,  A61L33/0011 ,  A61L33/18 ,  A61L2300/404 ,  A61L2300/42

摘要： Provided herein is a method of reducing a microbial infection of a heparinized surface wherein heparin precipitation is reduced as compared to a control. In some embodiments a composition comprising ethanol and isopropanol is applied to the surface. In other embodiments, two or more ethanol compositions are applied and removed sequentially from the surface prior to contacting the surface with a biological fluid, tissue or vessel, wherein the composition in each successive administration comprises an increased amount of ethanol. Also provided is a method of reducing a microbial infection of a surface comprising applying a mucilage extract from an Opuntia ficus indica species to the surface.

摘要翻译： 本文提供了减少肝素化表面的微生物感染的方法，其中与对照相比，肝素沉淀降低。 在一些实施方案中，将包含乙醇和异丙醇的组合物施加到表面。 在其它实施方案中，在将表面与生物流体，组织或容器接触之前，从表面依次施加和除去两种或更多种乙醇组合物，其中每次连续给药中的组合物包含增加量的乙醇。 还提供了减少表面微生物感染的方法，其包括将来自榕属的芸苔属植物的粘液提取物施用于表面。

公开(公告)号：US09839709B1

公开(公告)日：2017-12-12

申请号：US15155988

申请日：2016-05-16

申请人： Mark Lawrence Kayton ,  Norma Alcantar ,  Daniel Restrepo ,  Nicholas S. Laconi ,  Audrey Lynn Buttice ,  Michael Pierce Ebaugh

发明人： Mark Lawrence Kayton ,  Norma Alcantar ,  Daniel Restrepo ,  Nicholas S. Laconi ,  Audrey Lynn Buttice ,  Michael Pierce Ebaugh

IPC分类号： A61L2/18 ,  A01N65/08 ,  A61L33/00 ,  A61L33/18 ,  A61L29/08 ,  A61L29/06 ,  A61L29/00

CPC分类号： A61L2/18 ,  A01N31/02 ,  A01N65/08 ,  A61L29/005 ,  A61L29/06 ,  A61L29/08 ,  A61L33/0011 ,  A61L33/18 ,  A61L2300/404 ,  A61L2300/42

摘要： Provided herein is a method of reducing a microbial infection of a heparinized surface wherein heparin precipitation is reduced as compared to a control. In some embodiments a composition comprising ethanol and isopropanol is applied to the surface. In other embodiments, two or more ethanol compositions are applied and removed sequentially from the surface prior to contacting the surface with a biological fluid, tissue or vessel, wherein the composition in each successive administration comprises an increased amount of ethanol. Also provided is a method of reducing a microbial infection of a surface comprising applying a mucilage extract from an Opuntia ficus indica species to the surface.

公开(公告)号：US09339574B1

公开(公告)日：2016-05-17

申请号：US14818772

申请日：2015-08-05

申请人： Mark Lawrence Kayton ,  Norma Alcantar ,  Daniel Restrepo ,  Nicholas S. Laconi ,  Audrey Lynn Buttice ,  Michael Pierce Ebaugh

发明人： Mark Lawrence Kayton ,  Norma Alcantar ,  Daniel Restrepo ,  Nicholas S. Laconi ,  Audrey Lynn Buttice ,  Michael Pierce Ebaugh

IPC分类号： A61L2/18 ,  A01N31/02

CPC分类号： A61L2/18 ,  A01N31/02 ,  A01N65/08 ,  A61L29/005 ,  A61L29/06 ,  A61L29/08 ,  A61L33/0011 ,  A61L33/18 ,  A61L2300/404 ,  A61L2300/42

摘要： Provided herein is a method of reducing a microbial infection of a heparinized surface wherein heparin precipitation is reduced as compared to a control. In some embodiments a composition comprising ethanol and isopropanol is applied to the surface. In other embodiments, two or more ethanol compositions are applied and removed sequentially from the surface prior to contacting the surface with a biological fluid, tissue or vessel, wherein the composition in each successive administration comprises an increased amount of ethanol. Also provided is a method of reducing a microbial infection of a surface comprising applying a mucilage extract from an Opuntia ficus indica species to the surface.

公开(公告)号：US07943259B1

公开(公告)日：2011-05-17

申请号：US11958841

申请日：2007-12-18

申请人： Andres M. Cardenas-Valencia ,  Norma Alcantar ,  Xiaoling Ding ,  Ryan G. Toomey ,  Larry Langebrake

发明人： Andres M. Cardenas-Valencia ,  Norma Alcantar ,  Xiaoling Ding ,  Ryan G. Toomey ,  Larry Langebrake

IPC分类号： H01M8/16

CPC分类号： H01M8/16 ,  Y02E60/527

摘要： A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.

摘要翻译： 一种用于通过分配封装和分散到电化学电池的电室来改善电化学电源的系统和方法。 该方法的特征包括优化涉及所需能量产生反应的化学品的浓度水平。

公开(公告)号：US20100068264A1

公开(公告)日：2010-03-18

申请号：US12622693

申请日：2009-11-20

申请人： Norma Alcantar ,  Eva C. Williams ,  Ryan Toomey

发明人： Norma Alcantar ,  Eva C. Williams ,  Ryan Toomey

IPC分类号： A61K9/127

CPC分类号： A61K9/0085 ,  A61K47/36

摘要： Localized drug delivery systems are effective means to administer therapeutic concentrations and controlled release of drugs. A delivery system consisting of non-ionic surfactant vesicles (niosomes) packaged within a biodegradable, temperature and pH sensitive hydrogel network was developed. Drug behaviors were modeled using a fluorescent dye with similar physical properties as therapeutic drugs for cancer. The niosomes were embedded into a biodegradable hydrogel providing a stable niosome environment. A cross linked chitosan was used as the hydrogel, which is a liquid at room temperature, and gels inside the body. Depending on the conditions to which individual niosomes are exposed, the release rate can be controlled to last from 24 hours to more than 3 months.

摘要翻译： 局部给药系统是治疗浓度和控释药物的有效手段。 开发了一种由包装在可生物降解，温度和pH敏感的水凝胶网络内的非离子表面活性剂囊泡（niosomes）组成的递送系统。 使用具有与用于癌症的治疗药物相似的物理性质的荧光染料来模拟药物行为。 将Niosomes嵌入可生物降解的水凝胶中，提供稳定的niosome环境。 使用交联的壳聚糖作为水凝胶，其在室温下为液体，并在体内凝胶化。 根据个别鼻息肉的暴露条件，释放率可以控制在24小时至3个月以上。

公开(公告)号：US20080050445A1

公开(公告)日：2008-02-28

申请号：US11737271

申请日：2007-04-19

申请人： Norma Alcantar ,  Kristina Dearborn ,  Michael VanAuker ,  Ryan Toomey ,  Elizabeth Hood

发明人： Norma Alcantar ,  Kristina Dearborn ,  Michael VanAuker ,  Ryan Toomey ,  Elizabeth Hood

IPC分类号： A61K9/50

CPC分类号： A61K9/0014 ,  A61K9/0085 ,  A61K47/36

摘要： Taught herein is a drug-delivery system that includes encapsulating a therapeutic drug in a nanoparticle vesicle that is then embedded into a hydrogel network. The system allows for enhanced, two-fold control over the release rate of the drug. This technology will be particularly advantageous in treating malignant cancer cells such as those found in the brain. The invention will allow for decreased side effects and increased survival time in patients. This invention opens the door to other technological applications that require controlled release of chemical substances.

摘要翻译： 本文所述是药物递送系统，其包括将治疗药物包封在纳米颗粒囊泡中，然后将其嵌入水凝胶网络中。 该系统允许对药物的释放速率进行增强的双重控制。 该技术在治疗恶性癌细胞如脑中发现的这些细胞方面特别有利。 本发明将允许患者的副作用减少和生存时间增加。 本发明为需要化学物质控制释放的其他技术应用打开了大门。