公开(公告)号：US09429522B2

公开(公告)日：2016-08-30

申请号：US14332231

申请日：2014-07-15

Applicant: Massachusetts Institute of Technology

Inventor： Timothy M. Swager ,  Samuel W. Thomas, III ,  Koushik Venkatesan

IPC: G01N21/64 ,  G01N21/76 ,  G01N33/00 ,  C07F15/00 ,  C09K11/06 ,  G01N33/20

CPC classification number: G01N21/76 ,  C07F15/0086 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1092 ,  C09K2211/185 ,  G01N21/64 ,  G01N33/0057 ,  G01N33/20 ,  G01N2201/06113 ,  Y10T436/172307 ,  Y10T436/196666

Abstract: The present invention generally relates to emissive materials, devices, and related methods. In some cases, the present invention provides sensors and methods for the determination of analytes, wherein the analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. The analyte and the emissive material may interact via a chemical reaction, such as an oxidative addition reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be useful in the detection of a wide variety of analytes, such as toxins, chemical warfare agents, and explosives. The present invention also provides emissive compounds, and related methods, including metal complexes that are capable of interacting with an analyte to produce a change in the emission of the compound. Some advantages of the present invention include the determination of analytes with high specificity and sensitivity and the ability to fabricate simplified and highly portable devices.

公开(公告)号：US20150247805A1

公开(公告)日：2015-09-03

申请号：US14332231

申请日：2014-07-15

Applicant: Massachusetts Institute of Technology

Inventor： Timothy M. Swager ,  Samuel W. Thomas, III ,  Koushik Venkatesan

IPC: G01N21/76 ,  G01N21/64 ,  G01N33/20

CPC classification number: G01N21/76 ,  C07F15/0086 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1092 ,  C09K2211/185 ,  G01N21/64 ,  G01N33/0057 ,  G01N33/20 ,  G01N2201/06113 ,  Y10T436/172307 ,  Y10T436/196666

Abstract: The present invention generally relates to emissive materials, devices, and related methods. In some cases, the present invention provides sensors and methods for the determination of analytes, wherein the analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte.The analyte and the emissive material may interact via a chemical reaction, such as an oxidative addition reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be useful in the detection of a wide variety of analytes, such as toxins, chemical warfare agents, and explosives. The present invention also provides emissive compounds, and related methods, including metal complexes that are capable of interacting with an analyte to produce a change in the emission of the compound. Some advantages of the present invention include the determination of analytes with high specificity and sensitivity and the ability to fabricate simplified and highly portable devices.

Abstract translation: 本发明一般涉及发射材料，器件和相关方法。 在一些情况下，本发明提供用于测定分析物的传感器和方法，其中分析物可以通过例如在暴露于分析物时监测发光材料的光学信号的变化来确定。 分析物和发射材料可通过诸如氧化加成反应或其他化学，生物化学或生物相互作用（例如识别）的化学反应相互作用以形成新的发射物质。 在一些情况下，本发明可用于检测各种分析物，例如毒素，化学战剂和爆炸物。 本发明还提供发射化合物和相关方法，包括能够与分析物相互作用以产生化合物的发射变化的金属络合物。 本发明的一些优点包括具有高特异性和灵敏度的分析物的测定以及制造简化且高度便携的装置的能力。