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公开(公告)号：US20180289965A1
公开(公告)日：2018-10-11
申请号：US15946971
申请日：2018-04-06
Applicant: Medtronic, Inc.
Inventor： Dwight E. Nelson , Thaddeus S. Brink , Lance Zirpel
IPC: A61N1/36
Abstract: Techniques for delivering electrical stimulation therapy comprising a complex variation to at least one electrical stimulation parameter are described. In one example, processing circuitry of an implantable medical device (IMD) identifies a plurality of electrical stimulation parameters for at least one pulse train of electrical stimulation. The processing circuitry defines a complex variation to at least one electrical stimulation parameter of the plurality of electrical stimulation parameters. The processing circuitry modifies the at least one pulse train of electrical stimulation by introducing the complex variation to the electrical stimulation parameter function and controls a stimulation generator of the IMD to generate, as modified, the at least one pulse train of electrical stimulation.
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公开(公告)号：US20230233853A1
公开(公告)日：2023-07-27
申请号：US18193004
申请日：2023-03-30
Applicant: Medtronic, Inc.
Inventor： Lance Zirpel , Sudha B. Iyer , Xuan K. Wei
IPC: A61N1/36
CPC classification number: A61N1/36007 , A61N1/36178
Abstract: An implantable medical device (IMD) includes a memory configured to store a set of therapy parameters for subsensory electrical stimulation of a patient; and therapy delivery circuitry configured to deliver the subsensory electrical stimulation to at least one of a sacral nerve or tibial nerve based on the stored set of therapy parameters to provide immediate therapeutic effect caused by the ongoing delivery of the subsensory electrical stimulation to address incontinence, wherein a stimulation intensity of the subsensory electrical stimulation is less than 80% of a stimulation intensity at a sensory threshold, and wherein the patient does not perceive delivery of the subsensory electrical stimulation and perceives delivery of stimulation at the sensory threshold.
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公开(公告)号：US11638821B2
公开(公告)日：2023-05-02
申请号：US16942542
申请日：2020-07-29
Applicant: Medtronic, Inc.
Inventor： Lance Zirpel , Sudha B. Iyer , Xuan K. Wei
IPC: A61N1/36
Abstract: The disclosure describes example of subsensory electrical stimulation for providing therapy for incontinence. An implantable medical device (IMD) includes a memory configured to store a set of therapy parameters for subsensory electrical stimulation of a patient. The delivery of the subsensory electrical stimulation results in a therapeutic effect for incontinence therapy at a stimulation intensity that is in range of approximately 50% to 80% of a stimulation intensity at a sensory threshold, and the patient does not perceive delivery of the subsensory electrical stimulation and perceives delivery of stimulation at the sensory threshold. The IMD also includes therapy delivery circuitry configured to deliver the subsensory electrical stimulation based on the stored set of therapy parameters, including cycling the delivery of the subsensory electrical stimulation between an on-cycle and an off-cycle.
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公开(公告)号：US10765355B2
公开(公告)日：2020-09-08
申请号：US15964739
申请日：2018-04-27
Applicant: Medtronic, Inc.
Inventor： Dwight E. Nelson , Thaddeus S. Brink , Lance Zirpel , Adam P. Steiner
Abstract: This disclosure describes methods, systems, and devices configured to determine a timing of a future bladder related event of a patient. For example, a system includes processing circuitry configured to identify a timing of a plurality of bladder related events of a patient, determine, based on the timing of the plurality of bladder related events of the patient, a probability to experience a bladder related event function for the patient, the probability to experience a bladder related event function indicating a probability that the patient will experience a bladder related event at an elapsed time after a previous bladder related event, predict, based on the probability to experience a bladder related event function, a timing of a future bladder related event, and control delivery of a therapy to the patient based on the predicted timing of the future bladder related event.
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公开(公告)号：US20200230406A1
公开(公告)日：2020-07-23
申请号：US16744784
申请日：2020-01-16
Applicant: Medtronic, Inc.
Inventor： Thaddeus S. Brink , Thomas Adamski , Scott R. Stanslaski , Lance Zirpel , Jeffrey Herron
Abstract: A method includes monitoring a sensor signal and classifying a physiological marker of a patient based upon the sensor signal. The method also includes generating a control signal based on the classified physiological marker, the control signal controlling an implantable stimulation device to provide the electrical stimulation at a target site within the patient. The method further includes adapting one or more of a manner in which processor circuitry classifies the physiological markers, generates the control signal, or one or more stimulation parameters of a stimulation program based on the classified physiological markers or patient input so as to automatically adjust one or more of timing or the stimulation parameters of the electrical stimulation.
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Patent Agency Ranking
公开(公告)号：US12194301B2
公开(公告)日：2025-01-14
申请号：US17552813
申请日：2021-12-16
Applicant: Medtronic, Inc.
Inventor： Thaddeus S. Brink , Dwight E. Nelson , Xin Su , Lance Zirpel
Abstract: Devices, systems, and methods may manage therapy delivery to a patient based on one or more physiological markers. In some examples, a method includes detecting a physiological marker that occurs prior in time to a dysfunctional phase of a physiological cycle, wherein a dysfunctional state of the physiological cycle occurs during the dysfunctional phase without treatment, responsive to detecting the physiological marker, initiating a first phase of the physiological cycle having a duration of time. The method may also include, responsive to the first phase elapsing, controlling a therapy delivery module to deliver neurostimulation therapy during a second phase that begins prior to the dysfunctional phase, wherein the neurostimulation therapy is configured to treat the dysfunctional state.
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公开(公告)号：US11969592B2
公开(公告)日：2024-04-30
申请号：US18193004
申请日：2023-03-30
Applicant: Medtronic, Inc.
Inventor： Lance Zirpel , Sudha B. Iyer , Xuan K. Wei
IPC: A61N1/36
CPC classification number: A61N1/36007 , A61N1/36178
Abstract: An implantable medical device (IMD) includes a memory configured to store a set of therapy parameters for subsensory electrical stimulation of a patient; and therapy delivery circuitry configured to deliver the subsensory electrical stimulation to at least one of a sacral nerve or tibial nerve based on the stored set of therapy parameters to provide immediate therapeutic effect caused by the ongoing delivery of the subsensory electrical stimulation to address incontinence, wherein a stimulation intensity of the subsensory electrical stimulation is less than 80% of a stimulation intensity at a sensory threshold, and wherein the patient does not perceive delivery of the subsensory electrical stimulation and perceives delivery of stimulation at the sensory threshold.
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公开(公告)号：US20210031032A1
公开(公告)日：2021-02-04
申请号：US16942542
申请日：2020-07-29
Applicant: Medtronic, Inc.
Inventor： Lance Zirpel , Sudha B. Iyer , Xuan K. Wei
IPC: A61N1/36
Abstract: The disclosure describes example of subsensory electrical stimulation for providing therapy for incontinence. An implantable medical device (IMD) includes a memory configured to store a set of therapy parameters for subsensory electrical stimulation of a patient. The delivery of the subsensory electrical stimulation results in a therapeutic effect for incontinence therapy at a stimulation intensity that is in range of approximately 50% to 80% of a stimulation intensity at a sensory threshold, and the patient does not perceive delivery of the subsensory electrical stimulation and perceives delivery of stimulation at the sensory threshold. The IMD also includes therapy delivery circuitry configured to deliver the subsensory electrical stimulation based on the stored set of therapy parameters, including cycling the delivery of the subsensory electrical stimulation between an on-cycle and an off-cycle.
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公开(公告)号：US20170065821A1
公开(公告)日：2017-03-09
申请号：US15256242
申请日：2016-09-02
Applicant: Medtronic, Inc.
Inventor： Thaddeus S. Brink , Dwight E. Nelson , Xin Su , Lance Zirpel
Abstract: Devices, systems, and methods may manage therapy delivery to a patient based on one or more physiological markers. In some examples, a method includes detecting a physiological marker that occurs prior in time to a dysfunctional phase of a physiological cycle, wherein a dysfunctional state of the physiological cycle occurs during the dysfunctional phase without treatment, responsive to detecting the physiological marker, initiating a first phase of the physiological cycle having a duration of time. The method may also include, responsive to the first phase elapsing, controlling a therapy delivery module to deliver neurostimulation therapy during a second phase that begins prior to the dysfunctional phase, wherein the neurostimulation therapy is configured to treat the dysfunctional state.
Abstract translation: 设备，系统和方法可以基于一个或多个生理学标记来管理对患者的治疗递送。 在一些实例中，一种方法包括检测在时间上发生在生理周期的功能失调阶段之前的生理标志物，其中生理循环的功能失调状态在没有治疗的功能障碍阶段期间发生，响应于检测生理学标志，发起 生理周期的第一阶段具有持续时间。 所述方法还可以包括响应于第一阶段过去，控制治疗递送模块在开始功能失调阶段之前的第二阶段期间递送神经刺激疗法，其中神经刺激疗法被配置为治疗功能障碍状态。
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公开(公告)号：US20220331589A1
公开(公告)日：2022-10-20
申请号：US17719005
申请日：2022-04-12
Applicant: Medtronic, Inc.
Inventor： Katie C. Bittner , Sarah J. Offutt , Julia P. Slopsema , Leonid M. Litvak , Lance Zirpel , Lisa M. Jungbauer Nikolas , Katelynn M. Johnson , Simeng Zhang
Abstract: An example method includes delivering one or more electrical stimulation signals to a patient, sensing a composite stimulation-evoked signal comprising a composite of signals generated by one or more signal sources in response to the one or more electrical stimulation signals, and controlling delivery of electrical stimulation therapy to the patient based on the composite stimulation-evoked signal.
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