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    Substituted imidazole derivative
    1.
    发明授权
    Substituted imidazole derivative 有权
    取代的咪唑衍生物

    公开(公告)号：US07718801B2

    公开(公告)日：2010-05-18

    申请号：US11661486

    申请日：2005-08-30

    申请人： Mikako Kawamura ,  Takashi Hashihayata ,  Satoshi Sunami ,  Tetsuya Sugimoto ,  Fuyuki Yamamoto ,  Yoshiyuki Sato ,  Kaori Kamijo ,  Morihiro Mitsuya ,  Yoshikazu Iwasawa ,  Hideya Komatani

    发明人： Mikako Kawamura ,  Takashi Hashihayata ,  Satoshi Sunami ,  Tetsuya Sugimoto ,  Fuyuki Yamamoto ,  Yoshiyuki Sato ,  Kaori Kamijo ,  Morihiro Mitsuya ,  Yoshikazu Iwasawa ,  Hideya Komatani

    IPC分类号： C07D239/00 ,  C07D239/02

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The present invention relates to a compound represented by Formula [I] or a pharmaceutically acceptable salt or ester thereof: wherein: X1, X2, X3, and X4, which may be identical or different, are each C or N, provided that none to two of X1, X2, X3, and X4 is/are N; Y is CH or N; R1, R1′, R2, R2′, R3, R3′, R4, and R4′, which may be identical or different, are each a hydrogen atom, a lower alkyl group, or the like; R5 is a hydrogen atom or a methyl group; R6 and R7, which may be identical or different, are each a hydrogen atom, a lower alkyl group, or the like; R8 and R8′, which may be identical or different, are each a hydrogen atom, a lower alkyl group, or the like; R9 is an aryl group or a heteroaryl group which may be substituted; and n is an integer from 1 to 3, and a PLK1 inhibitor or an anticancer agent containing the same.

    摘要翻译： 本发明涉及由式[I]表示的化合物或其药学上可接受的盐或酯：其中：X 1，X 2，X 3和X 4可以相同或不同，各自为C或N，条件是 X1，X2，X3和X4中的两个为N; Y是CH或N; R1，R1'，R2，R2'，R3，R3'，R4和R4'可以相同或不同，分别为氢原子，低级烷基等; R5是氢原子或甲基; R 6和R 7可以相同或不同，分别为氢原子，低级烷基等; R 8和R 8'可以相同或不同，分别为氢原子，低级烷基等; R9是可以被取代的芳基或杂芳基; n为1〜3的整数，PLK1抑制剂或含有该PLK1抑制剂的抗癌剂。

    DIARYLMETHYLAMIDE DERIVATIVE HAVING MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISM
    5.
    发明申请
    DIARYLMETHYLAMIDE DERIVATIVE HAVING MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISM 审中-公开
    具有富马酸浓度的HORMONE受体拮抗剂的二甲基甲酰胺衍生物

    公开(公告)号：US20110015198A1

    公开(公告)日：2011-01-20

    申请号：US12919036

    申请日：2009-03-26

    申请人： Kaori Kamijo ,  Minoru Moriya ,  Takao Suzuki ,  Akihiro Takezawa

    发明人： Kaori Kamijo ,  Minoru Moriya ,  Takao Suzuki ,  Akihiro Takezawa

    IPC分类号： A61K31/438 ,  C07D491/107 ,  C07D401/14 ,  C07D487/04 ,  C07D471/04 ,  A61K31/4545 ,  A61K31/437 ,  A61K31/5025 ,  A61P3/04 ,  A61P3/10 ,  A61P1/16 ,  A61P25/24 ,  A61P25/22

    CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/20

    摘要： [Problem] To provide a melanin-concentrating hormone receptor antagonist useful as a pharmaceutical agent for central diseases, circulatory diseases, and metabolic diseases.[Means for Resolution] Provided is a diarylmethylamide derivative represented by formula (I): Wherein R1a, R1b, R2a, R2b, R3a, and R3b independently represent a hydrogen atom or the like, R4 represents a hydrogen atom, C1-6 alkyl, or the like, R5 represents a hydrogen atom or the like, Z represents C1-6 alkyl or the like, or R4 and Z together form a 4- to 6-membered nitrogen-containing hetero ring, Y1 represents H or the like, Y2 represents H, or Y1 and Y2 together form —O—CH2—, W represents C, SO, or the like, Ar1 represents 6-membered aryl or the like, Ar2 represents 6-membered aryl or the like, and ring A represents a benzene ring, a pyridine ring, or the like.

    摘要翻译： [问题]提供可用作中枢疾病，循环系统疾病和代谢疾病的药剂的黑色素浓缩激素受体拮抗剂。 [解决方法]提供由式（I）表示的二芳基甲基酰胺衍生物：其中R1a，R1b，R2a，R2b，R3a和R3b独立地表示氢原子等，R4表示氢原子，C1-6烷基， 等等，R 5表示氢原子等，Z表示C 1-6烷基等，或者R 4和Z一起形成4至6元含氮杂环，Y1表示H等，Y2表示H等 表示H或Y1和Y2一起形成-O-CH 2 - ，W表示C，SO等，Ar 1表示6元芳基等，Ar 2表示6元芳基等，环A表示 苯环，吡啶环等。