公开(公告)号：US20230242908A1

公开(公告)日：2023-08-03

申请号：US18012094

申请日：2021-06-23

Applicant: ModernaTX, Inc.

Inventor： David Reid ,  Ruchi Jain ,  Alicia Bicknell ,  Caroline Kohrer

IPC: C12N15/11 ,  A61K9/16 ,  C12N15/88 ,  C12N15/67

CPC classification number: C12N15/11 ,  A61K9/1617 ,  C12N15/88 ,  C12N15/67

Abstract: The disclosure features a polynucleotide encoding a polypeptide, which polynucleotide comprises: a 5′UTR described herein; a coding region comprising a payload and a stop element described herein; and a 3′UTR described herein, and LNP compositions comprising the same. The polynucleotides and/or LNP compositions of the present disclosure can: increase the level and/or activity of the payload by increasing the half-life and/or duration of expression of the polynucleotide encoding the payload or of the payload polypeptide. Also disclosed herein are methods of treating a disease or disorder in a subject using the LNP compositions of the present disclosure.