公开(公告)号：US10428106B2

公开(公告)日：2019-10-01

申请号：US16008655

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Matthew Stanton ,  Thomas Steele

IPC: C07H21/00 ,  C07H21/02

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

公开(公告)号：US10563195B2

公开(公告)日：2020-02-18

申请号：US16008662

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Matthew Stanton ,  Thomas Steele

IPC: C12N15/11 ,  C12N15/10 ,  C07H21/02 ,  C07D473/18 ,  C07D473/34

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the cap analogs.

公开(公告)号：US10570388B2

公开(公告)日：2020-02-25

申请号：US16008658

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Matthew Stanton ,  Thomas Steele

IPC: C12N15/11 ,  C12N15/10 ,  C07H21/02 ,  C07D473/18 ,  C07D473/34

Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the cap analogs.