公开(公告)号：US20240294492A1

公开(公告)日：2024-09-05

申请号：US18628594

申请日：2024-04-05

Applicant: NEUMORA THERAPEUTICS, INC.

Inventor： Paul Dransfield ,  Dilinie Fernando ,  James Harvey ,  Brian Sparling ,  John Stellwagen ,  Zhihua Ma ,  Anne-Marie Beausoleil ,  Ryan Hudson

IPC: C07D401/04

CPC classification number: C07D401/04

Abstract: The present disclosure relates to compounds of Formula (I).




and pharmaceutically acceptable salts thereof, wherein the variable are as described herein, and compositions and uses of same for treating neurological disorders.

公开(公告)号：US11993580B1

公开(公告)日：2024-05-28

申请号：US18526960

申请日：2023-12-01

Applicant: NEUMORA THERAPEUTICS, INC.

Inventor： Paul Dransfield ,  Dilinie Fernando ,  James Harvey ,  Brian Sparling ,  John Stellwagen ,  Zhihua Ma ,  Anne-Marie Beausoleil ,  Ryan Hudson

IPC: C07D401/04

CPC classification number: C07D401/04

Abstract: The present disclosure relates to compounds of Formula (I),




and pharmaceutically acceptable salts thereof, wherein the variable are as described herein, and compositions and uses of same for treating neurological disorders.

公开(公告)号：US20230365534A1

公开(公告)日：2023-11-16

申请号：US18316994

申请日：2023-05-12

Applicant: Neumora Therapeutics, Inc.

Inventor： Anne-Marie Beausoleil ,  Ryan Hudson

IPC: C07D403/12 ,  C07D403/14 ,  C07D407/12 ,  C07D237/20

CPC classification number: C07D403/12 ,  C07D403/14 ,  C07D407/12 ,  C07D237/20

Abstract: Compounds are provided for modulating NLRP3 inflammasome generally, or for treating a NLRP3 inflammasome dependent condition more specifically, by contacting the NLRP3 inflammasome or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I):




or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein X, R1, R2, R3, R4, R5, R8, R9, R10, R1, R12, R13, and n are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

公开(公告)号：US20240246928A1

公开(公告)日：2024-07-25

申请号：US18526960

申请日：2023-12-01

Applicant: NEUMORA THERAPEUTICS, INC.

Inventor： Paul Dransfield ,  Dilinie Fernando ,  James Harvey ,  Brian Sparling ,  John Stellwagen ,  Zhihua Ma ,  Anne-Marie Beausoleil ,  Ryan Hudson

IPC: C07D401/04

CPC classification number: C07D401/04

Abstract: The present disclosure relates to compounds of Formula (I),




and pharmaceutically acceptable salts thereof, wherein the variable are as described herein, and compositions and uses of same for treating neurological disorders.