公开(公告)号：US20170267659A1

公开(公告)日：2017-09-21

申请号：US15309997

申请日：2015-05-11

Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.

Inventor： Hironobu YOSHINO ,  Yasuhiro UMEDA ,  Jun TAKEOKA ,  Akihiro NAGAYA ,  Yudai SUGAWARA ,  Madoka YOSHINO

IPC: C07D401/06 ,  C07D213/64

CPC classification number: C07D401/06 ,  C07B53/00 ,  C07B57/00 ,  C07D213/50 ,  C07D213/64 ,  C07D213/84 ,  C07D213/89

Abstract: To provide a method for producing a compound represented by the formula (1) which is a 2-pyridone compound useful as a pharmaceutical or an intermediate for a pharmaceutical, etc. at a high yield. A method for producing a 2-pyridone compound represented by the formula (1), which comprises reacting a 6-benzoyl-2-pyridone compound represented by the formula (3) with a sulfone compound represented by the formula (4):

公开(公告)号：US20160168161A1

公开(公告)日：2016-06-16

申请号：US14907798

申请日：2014-07-22

Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.

Inventor： Akihiro NAGAYA ,  Madoka YOSHINO ,  Hironobu YOSHINO

IPC: C07D491/052 ,  C07C57/145 ,  C07D311/42 ,  C07D311/70

CPC classification number: C07D491/052 ,  C07C57/145 ,  C07D311/42 ,  C07D311/70

Abstract: There is provided a method for producing with a high efficiency a heterocyclic compound that is useful as a raw material for pharamaceuticals. A novel production method for producing 2,2,7,9-tetramethyl-2H-pyrano[2,3-g]quinoline (compound (6)) that has a quinoline ring and a chromene ring using N-(3-acetyl-4-hydroxyphenyl)butylamide (compound (1′)) that is commercially available as a raw material for pharamaceuticals or the like as a starting raw material; and a method for purifying compound (6), characterized by purifying by subjecting it to conversion into a salt form.

Abstract translation: 提供了可用作药物原料的杂环化合物的高效生产方法。 一种具有喹啉环和色烯环的2,2,7,9-四甲基-2H-吡喃并[2,3-g]喹啉（化合物（6））的制备方法，使用N-（3-乙酰基 - 4-羟基苯基）丁酰胺（化合物（1'）），作为起始原料的药物等的原料可商购获得; 和化合物（6）的纯化方法，其特征在于，使其转化成盐形式进行纯化。