公开(公告)号：US20210346387A1

公开(公告)日：2021-11-11

申请号：US17181896

申请日：2021-02-22

Applicant: NOVARTIS AG

Inventor： Alex CORTEZ ,  Bernhard Hubert GEIERSTANGER ,  Timothy Z. HOFFMAN ,  Shailaja KASIBHATLA ,  Tetsuo UNO ,  Xing WANG ,  Tom Yao-Hsiang WU

IPC: A61K31/52 ,  A61K47/68 ,  C07D487/04 ,  C07H15/26 ,  C07K16/28 ,  C07K16/32

Abstract: Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies.

公开(公告)号：US20190382441A1

公开(公告)日：2019-12-19

申请号：US16439204

申请日：2019-06-12

Applicant: NOVARTIS AG

Inventor： Bernhard Hubert GEIERSTANGER ,  Jan GRUNEWALD ,  Yunho JIN ,  Weijia OU ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG

IPC: C07K5/02 ,  A61K47/68 ,  C07K7/02 ,  C07K16/32

Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

公开(公告)号：US20180244717A1

公开(公告)日：2018-08-30

申请号：US15961531

申请日：2018-04-24

Applicant: NOVARTIS AG

Inventor： Bernhard Hubert GEIERSTANGER ,  Jan GRUNEWALD ,  Yunho JIN ,  Weijia OU ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG

IPC: C07K5/02 ,  C07K7/02 ,  A61K47/68 ,  C07K16/32

CPC classification number: C07K5/0205 ,  A61K47/6817 ,  A61K47/6851 ,  C07K7/02 ,  C07K16/32

Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.