公开(公告)号：US20240092918A1

公开(公告)日：2024-03-21

申请号：US18164519

申请日：2023-02-03

Applicant: Novartis AG

Inventor： Steven BENDER ,  Tracy CHARLTON ,  Anna GALKIN ,  Bernhard Hubert GEIERSTANGER ,  Scott Martin GLASER ,  Shailaja KASIBHATLA ,  Mark KNUTH ,  Sabine ROTTMANN ,  Sarah RUE ,  Glen SPRAGGON ,  Tetsuo UNO

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

CPC classification number: C07K16/2866 ,  A61K47/6803 ,  A61K47/6849 ,  A61P35/00 ,  A61K2039/505

Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US20210346387A1

公开(公告)日：2021-11-11

申请号：US17181896

申请日：2021-02-22

Applicant: NOVARTIS AG

Inventor： Alex CORTEZ ,  Bernhard Hubert GEIERSTANGER ,  Timothy Z. HOFFMAN ,  Shailaja KASIBHATLA ,  Tetsuo UNO ,  Xing WANG ,  Tom Yao-Hsiang WU

IPC: A61K31/52 ,  A61K47/68 ,  C07D487/04 ,  C07H15/26 ,  C07K16/28 ,  C07K16/32

Abstract: Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies.

公开(公告)号：US20210170043A1

公开(公告)日：2021-06-10

申请号：US16669291

申请日：2019-10-30

Applicant: NOVARTIS AG ,  ADURO BIOTECH, INC.

Inventor： Lisa BARNETT ,  Steven BENDER ,  Charles Y. CHO ,  Sarah COX ,  Jonathan Deane ,  Scott Martin GLASER ,  Xueshi Hao ,  Shailaja KASIBHATLA ,  Weijia OU ,  Tetsuo UNO ,  Yongqin WAN ,  Ben WEN ,  Tom Yao-Hsiang WU

IPC: A61K47/68 ,  C07K16/28 ,  A61K31/688 ,  A61P35/00

Abstract: Provided herein are immunoconjugates comprising an anti-DC-SIGN antibody conjugated to a STING agonist. Also disclosed are methods of making the immunoconjugates and methods of treating cancer using the immunoconjugates.

公开(公告)号：US20200216548A1

公开(公告)日：2020-07-09

申请号：US16482173

申请日：2018-02-01

Applicant: NOVARTIS AG

Inventor： Steven BENDER ,  Tracy CHARLTON ,  Anna GALKIN ,  Bernhard Hubert GEIERSTANGER ,  Scott Martin GLASER ,  Shailaja KASIBHATLA ,  Mark KNUTH ,  Sabine ROTTMANN ,  Sarah RUE ,  Glen SPRAGGON ,  Tetsuo UNO

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.