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公开(公告)号：US20170088544A1
公开(公告)日：2017-03-30
申请号：US15285234
申请日：2016-10-04
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Qinwei Wang , David Ho , Tulay Polat , Laxman Nallan , Patrick Soon-Shiong
IPC分类号： C07D403/14 , C07D413/14 , A61K31/5377 , A61K31/541 , A61K31/506 , C07D401/14
CPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
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2.发明授权公开(公告)号：US09458137B2
公开(公告)日：2016-10-04
申请号：US14440817
申请日：2013-11-05
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Qinwei Wang , David Ho , Tulay Polat , Laxman Nallan , Patrick Soon-Shiong
IPC分类号： A61K31/506 , C07D403/14 , A61K45/06 , C07D403/12 , C07D401/14 , A61K31/5377 , A61K31/541
CPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
摘要翻译： 本发明一般涉及化合物用于治疗各种疾病，疾病和病理状况，更具体地涉及使用取代的吲哚-5-醇衍生物调节蛋白激酶和治疗蛋白激酶介导的疾病。
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公开(公告)号：US20170135992A1
公开(公告)日：2017-05-18
申请号：US15359102
申请日：2016-11-22
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Chengzhi Yu , Forrest Arp , Paul Weingarten , Patrick Soon-Shiong
IPC分类号： A61K31/425
CPC分类号： A61K31/425 , C07D275/02 , C07D279/02 , C07D291/06 , C07D417/12 , C07D419/12 , C07D471/04
摘要： The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angiogenesis mediated diseases.
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公开(公告)号：US10245261B2
公开(公告)日：2019-04-02
申请号：US15379696
申请日：2016-12-15
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Qinwei Wang , David Ho , Tulay Polat , Laxman Nallan , Patrick Soon-Shiong
IPC分类号： A61K31/506 , A61K31/5377 , A61K31/541 , C07D401/14 , C07D403/14 , C07D413/14
摘要： The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
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公开(公告)号：US10183013B2
公开(公告)日：2019-01-22
申请号：US15359102
申请日：2016-11-22
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Chengzhi Yu , Forrest Arp , Paul Weingarten , Patrick Soon-Shiong
IPC分类号： A61K31/425 , C07D417/12 , C07D419/12 , C07D471/04 , C07D275/02 , C07D279/02 , C07D291/06
摘要： The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angiogenesis mediated diseases.
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公开(公告)号：US10160749B2
公开(公告)日：2018-12-25
申请号：US15285234
申请日：2016-10-04
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Qinwei Wang , David Ho , Tulay Polat , Laxman Nallan , Patrick Soon-Shiong
IPC分类号： A61K31/506 , C07D403/14 , A61K45/06 , C07D403/12 , C07D401/14 , A61K31/5377 , A61K31/541 , C07D417/14 , C07D413/14
摘要： The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
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7.发明授权Cyclic sulfonamide containing derivatives as inhibitors of hedgehog signaling pathway 有权含有磺酰胺的环状磺酰胺作为刺猬蛋白信号通路抑制剂的衍生物公开(公告)号：US09499539B2
公开(公告)日：2016-11-22
申请号：US14440796
申请日：2013-11-04
申请人： NantBioScience, Inc.
发明人： Chunlin Tao , Chengzhi Yu , Forrest Arp , Paul Weingarten , Patrick Soon-Shiong
IPC分类号： C07D275/00 , C07D471/04 , C07D417/12 , C07D419/12 , C07D275/02 , C07D279/02 , C07D291/06
CPC分类号： A61K31/425 , C07D275/02 , C07D279/02 , C07D291/06 , C07D417/12 , C07D419/12 , C07D471/04
摘要： The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angiogenesis mediated diseases.
摘要翻译： 本发明一般涉及产生和使用含环状磺酰胺的衍生物以抑制刺猬蛋白信号通路，以及这些化合物用于治疗过度增殖性疾病和血管生成介导的疾病的用途。
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公开(公告)号：US20180086752A1
公开(公告)日：2018-03-29
申请号：US15563813
申请日：2016-04-01
发明人： Shahrooz Rabizadeh , Kayvan Niazi , Sasha Buzko , Paul Weingarten , Heather McFarlane , Anna Juncker-Jensen , Justin Golovato , Patrick Soon-Shiong , Chunlin Tao , David Ho
IPC分类号： C07D417/14 , C07D417/12 , C07F9/6558 , C07D471/06 , C07D417/04
CPC分类号： C07D417/14 , A61K31/427 , A61P35/00 , C07D277/46 , C07D417/04 , C07D417/12 , C07D471/06 , C07F9/65583
摘要： Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.
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