公开(公告)号：US20100297194A1

公开(公告)日：2010-11-25

申请号：US12770299

申请日：2010-04-29

申请人： Nathaniel Catron ,  Michael G. Fickes ,  Cristina M. Fischer ,  Rajeev Gokhale ,  Anthony R. Haight ,  Katherine Heemstra ,  David Hill ,  Martin Knobloch ,  Drazen Kostelac ,  Justin S. Lafountaine ,  Yanxia Li ,  Bernd Liepold ,  Kennan Marsh ,  Jonathan M. Miller ,  Claudia Packhaeuser ,  Yeshwant D. Sanzgiri ,  Eric A. Schmitt ,  Yi Shi ,  Norbert Steiger ,  Ping Tong ,  Huailiang Wu ,  Geoff G.Z. Zhang ,  Deliang Zhou

发明人： Nathaniel Catron ,  Michael G. Fickes ,  Cristina M. Fischer ,  Rajeev Gokhale ,  Anthony R. Haight ,  Katherine Heemstra ,  David Hill ,  Martin Knobloch ,  Drazen Kostelac ,  Justin S. Lafountaine ,  Yanxia Li ,  Bernd Liepold ,  Kennan Marsh ,  Jonathan M. Miller ,  Claudia Packhaeuser ,  Yeshwant D. Sanzgiri ,  Eric A. Schmitt ,  Yi Shi ,  Norbert Steiger ,  Ping Tong ,  Huailiang Wu ,  Geoff G.Z. Zhang ,  Deliang Zhou

IPC分类号： A61K31/5377 ,  A61K33/04 ,  A61K9/14 ,  A61P35/00

CPC分类号： A61K31/5377 ,  A61K9/08 ,  A61K9/10 ,  A61K9/146 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/4858 ,  A61K9/4866

摘要： An orally deliverable pharmaceutical composition comprises as a sole or first active ingredient a compound of Formula I defined herein or a pharmaceutically acceptable salt thereof, for example ABT-263 free base or ABT-263 bis-HCl salt, dispersed, in a free base equivalent amount of at least about 2.5% by weight of the composition, in a pharmaceutically acceptable carrier; wherein said active ingredient is in solid-state form and/or the composition further comprises, dispersed in the carrier, a pharmaceutically acceptable heavier-chalcogen antioxidant in an amount effective to inhibit oxidation of the active ingredient at a thioether linkage thereof. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

摘要翻译： 可口服递送的药物组合物包含作为唯一或第一活性成分的本文定义的式I化合物或其药学上可接受的盐，例如ABT-263游离碱或ABT-263双-HCl盐，以游离碱当量 至少约2.5重量％的组合物，在药学上可接受的载体中; 其中所述活性成分是固态形式和/或所述组合物还包含以有效抑制活性成分在其硫醚键的氧化的量分散在载体中的药学上可接受的较重硫族元素抗氧化剂。 该组合物适合于有需要的受试者的口服给药，用于治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病。

公开(公告)号：US20100311751A1

公开(公告)日：2010-12-09

申请号：US12796061

申请日：2010-06-08

申请人： Eric A. Schmitt ,  Ping Tong ,  Katherine Heemstra ,  Cristina M. Fischer ,  Huailiang Wu ,  Jonathan Mark Miller ,  Yanxia Li ,  Justin S. Lafountaine

发明人： Eric A. Schmitt ,  Ping Tong ,  Katherine Heemstra ,  Cristina M. Fischer ,  Huailiang Wu ,  Jonathan Mark Miller ,  Yanxia Li ,  Justin S. Lafountaine

IPC分类号： A61K31/5377 ,  A61P35/00

CPC分类号： A61K31/495 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/19 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/4858 ,  A61K9/4866 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44

摘要： A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound, e.g., ABT-263, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

摘要翻译： 促细胞凋亡的固体分散体基本上是非结晶形式包含分散在固体基质中的Bcl-2家族蛋白质抑制化合物，例如ABT-263，其包含（a）药学上可接受的水溶性聚合物载体和（ b）药学上可接受的表面活性剂。 制备这种固体分散体的方法包括将化合物，聚合物载体和表面活性剂溶解在合适的溶剂中，并除去溶剂以提供包含聚合物载体和表面活性剂的固体基质，并使化合物分散在基本上不结晶 形成。 该固体分散体适合于需要其的受试者口服给药以治疗以一种或多种抗凋亡Bcl-2家族蛋白（例如癌症）过表达为特征的疾病。

公开(公告)号：US20140013825A1

公开(公告)日：2014-01-16

申请号：US13982296

申请日：2011-12-31

申请人： Weiping Liu ,  Dongmei Zhang ,  Yizhu Zheng ,  Xu Wang ,  Jiazhi Su ,  Xiaoxing Ma ,  Jun Liu ,  Zhiyuan Li ,  Xinjing Wang ,  Min Li ,  Yizhuo Gu ,  Chaobo Xin ,  Yanxia Li ,  Zuoguang Zhang

发明人： Weiping Liu ,  Dongmei Zhang ,  Yizhu Zheng ,  Xu Wang ,  Jiazhi Su ,  Xiaoxing Ma ,  Jun Liu ,  Zhiyuan Li ,  Xinjing Wang ,  Min Li ,  Yizhuo Gu ,  Chaobo Xin ,  Yanxia Li ,  Zuoguang Zhang

IPC分类号： G01N15/08

CPC分类号： G01N15/082 ,  G01N15/0826 ,  G01N2015/086

摘要： An apparatus for testing the air permeability in the thickness direction of a resin matrix composite material layer includes a mold having a cavity and a covering plate, a loading apparatus, a temperature controlling apparatus, a vacuuming apparatus, and a flow detecting element. An air inlet is connected to the flow detecting element, and an air outlet is connected to the vacuuming apparatus. The covering plate has a through-hole with upper and lower ventilation pieces. The loading apparatus addresses the upper ventilation piece. A test specimen is laid flat between the ventilation pieces. Employment of the present invention allows for accurate testing of air permeability of pre-impregnated material in the thickness direction of the resin matrix composite material layer under different pressure and temperature conditions.

摘要翻译： 用于测试树脂基复合材料层的厚度方向上的透气度的装置包括具有空腔和盖板的模具，装载装置，温度控制装置，抽真空装置和流量检测元件。 空气入口连接到流量检测元件，并且空气出口连接到抽真空装置。 覆盖板具有带有上部和下部通风件的通孔。 装载装置解决上部通风件。 试样在通气件之间平放。 本发明的使用允许在不同的压力和温度条件下，在树脂基质复合材料层的厚度方向上精确测试预浸渍材料的透气性。

公开(公告)号：US20140013826A1

公开(公告)日：2014-01-16

申请号：US13982332

申请日：2011-12-31

申请人： Weiping Liu ,  Dongmei Zhang ,  Xiaoxing Ma ,  Jun Liu ,  Zhiyuan Li ,  Xinjing Wang ,  Yizhu Zheng ,  Xu Wang ,  Jiazhi Su ,  Chaobo Xin ,  Yizhuo Gu ,  Min Li ,  Yanxia Li ,  Zuoguang Zhang

发明人： Weiping Liu ,  Dongmei Zhang ,  Xiaoxing Ma ,  Jun Liu ,  Zhiyuan Li ,  Xinjing Wang ,  Yizhu Zheng ,  Xu Wang ,  Jiazhi Su ,  Chaobo Xin ,  Yizhuo Gu ,  Min Li ,  Yanxia Li ,  Zuoguang Zhang

IPC分类号： G01N15/08

CPC分类号： G01N15/0826 ,  G01N2015/086

摘要： An apparatus for testing the gas permeability on the inward facing direction of a pre-impregnated resin matrix composite material layer includes a mold, a loading apparatus, a temperature control apparatus, a vacuuming apparatus, and a flow detecting element. A test specimen is laid flat inside the mold between airtight sealing elements that leave exposed two ends of the test specimen on the inward facing direction of the layer. An air inlet and an air outlet respectively are arranged on the mold and correspond to the two exposed ends of the test specimen. The inlet is connected to the flow detecting element, and the outlet is connected to the vacuuming apparatus. Air is forced to move in a vacuumed cavity along the inward facing direction of the layer. Testing of air permeability of pre-impregnated material in solidification technique is allowed via adjustments of pressure and temperature.

摘要翻译： 用于测试预浸渍树脂基复合材料层的向内方向上的透气性的装置包括模具，装载装置，温度控制装置，抽真空装置和流量检测元件。 将试样放置在模具内的密封密封元件之间，将试件的暴露的两端留在层的向内的方向上。 分别在模具上设置进气口和出气口，对应于试样的两个暴露端。 入口连接到流量检测元件，出口连接到抽真空装置。 空气被迫沿着层的向内的方向在真空腔中移动。 通过调节压力和温度，允许在固化技术中测试预浸渍材料的透气性。

公开(公告)号：US20070080762A1

公开(公告)日：2007-04-12

申请号：US11633850

申请日：2006-12-04

申请人： Heinz Bohlen ,  Yanxia Li ,  Paul Krzeminski ,  Edmund Davies ,  Robert Tornoe

发明人： Heinz Bohlen ,  Yanxia Li ,  Paul Krzeminski ,  Edmund Davies ,  Robert Tornoe

IPC分类号： H01P7/06

CPC分类号： H01J25/04 ,  H01J23/005 ,  H01J2223/005 ,  H01J2225/04

摘要： An inductive output tube (IOT) operates in a frequency range above 1000 MHz. An output window may be provided to separate a vacuum portion of the IOT from an atmospheric pressure portion of the IOT, the output window being surrounded by a cooling air manifold, the manifold including an air input port and a plurality of apertures permitting cooling air to move from the port, through the manifold and into the atmospheric pressure portion of the IOT. The output cavity may include a liquid coolant input port; a lower circular coolant channel coupled to receive liquid coolant from the liquid coolant input port; a vertical coolant channel coupled to receive liquid coolant from the lower circular coolant channel; an upper circular coolant channel coupled to receive liquid coolant from the vertical coolant channel; and a liquid coolant exhaust port coupled to receive liquid coolant from the upper circular coolant channel.

摘要翻译： 感应输出管（IOT）在1000 MHz以上的频率范围内工作。 可以提供输出窗口以将IOT的真空部分与IOT的大气压部分分离，输出窗被冷却空气歧管包围，歧管包括空气输入端口和多个孔，允许冷却空气 从端口移动通过歧管并进入IOT的大气压力部分。 输出腔可以包括液体冷却剂输入端口; 下部圆形冷却剂通道，其耦合以从液体冷却剂输入端口接收液体冷却剂; 垂直冷却剂通道，其联接以从下部圆形冷却剂通道接收液体冷却剂; 上部圆形冷却剂通道，其联接以从垂直冷却剂通道接收液体冷却剂; 以及液体冷却剂排出口，其联接以从上部圆形冷却剂通道接收液体冷却剂。

公开(公告)号：US08263079B2

公开(公告)日：2012-09-11

申请号：US13073004

申请日：2011-03-28

申请人： Jacqueline Francoise Doody ,  Yanxia Li

发明人： Jacqueline Francoise Doody ,  Yanxia Li

IPC分类号： A61K39/395 ,  C12P21/08

CPC分类号： C07K16/2866 ,  A61K39/39541 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  A61K2300/00

摘要： The invention provides a human antibody that binds human CSF-1R with high affinity. Antibodies of the present invention have significant advantages over the antibodies known in the art by being multifunctional: inhibiting signaling of CSF-1R, internalizing and inducing CSF-1R degradation and stimulating ADCC in cell including tumors, macrophages and monocytes. They are also shown to be effective in treating leukemia, breast, endometrial and prostate cancer alone or in combination with docetaxel, paclitaxel, Herceptin® or doxorubicin.

摘要翻译： 本发明提供以高亲和力结合人CSF-1R的人抗体。 本发明的抗体相对于本领域已知的抗体具有多功能性：通过抑制CSF-1R的信号传导，内化和诱导CSF-1R降解并在包括肿瘤，巨噬细胞和单核细胞的细胞中刺激ADCC，具有显着的优点。 它们也被证明可以单独治疗白血病，乳腺癌，子宫内膜癌和前列腺癌，或与多西紫杉醇，紫杉醇，赫赛汀或多柔比星组合有效。

公开(公告)号：US07145297B2

公开(公告)日：2006-12-05

申请号：US10982192

申请日：2004-11-04

申请人： Heinz P. Bohlen ,  Yanxia Li ,  Paul A. Krzeminski ,  Edmund T. Davies ,  Robert N. Tomoe

发明人： Heinz P. Bohlen ,  Yanxia Li ,  Paul A. Krzeminski ,  Edmund T. Davies ,  Robert N. Tomoe

IPC分类号： H05H13/00 ,  H01J25/08

CPC分类号： H01J25/04 ,  H01J23/005 ,  H01J2223/005 ,  H01J2225/04

摘要： An inductive output tube (IOT) operates in a frequency range above 1000 MHz. An output window may be provided to separate a vacuum portion of the IOT from an atmospheric pressure portion of the IOT, the output window being surrounded by a cooling air manifold, the manifold including an air input port and a plurality of apertures permitting cooling air to move from the port, through the manifold and into the atmospheric pressure portion of the IOT. The output cavity may include a liquid coolant input port; a lower circular coolant channel coupled to receive liquid coolant from the liquid coolant input port; a vertical coolant channel coupled to receive liquid coolant from the lower circular coolant channel; an upper circular coolant channel coupled to receive liquid coolant from the vertical coolant channel; and a liquid coolant exhaust port coupled to receive liquid coolant from the upper circular coolant channel.

摘要翻译： 感应输出管（IOT）在1000 MHz以上的频率范围内工作。 可以提供输出窗口以将IOT的真空部分与IOT的大气压部分分离，输出窗被冷却空气歧管包围，歧管包括空气输入端口和多个孔，允许冷却空气 从端口移动通过歧管并进入IOT的大气压力部分。 输出腔可以包括液体冷却剂输入端口; 下部圆形冷却剂通道，其耦合以从液体冷却剂输入端口接收液体冷却剂; 垂直冷却剂通道，其联接以从下部圆形冷却剂通道接收液体冷却剂; 上部圆形冷却剂通道，其联接以从垂直冷却剂通道接收液体冷却剂; 以及液体冷却剂排出口，其联接以从上部圆形冷却剂通道接收液体冷却剂。

公开(公告)号：US20060091831A1

公开(公告)日：2006-05-04

申请号：US10982192

申请日：2004-11-04

申请人： Heinz Bohlen ,  Yanxia Li ,  Paul Krzeminski ,  Edmund Davies ,  Robert Tornoe

发明人： Heinz Bohlen ,  Yanxia Li ,  Paul Krzeminski ,  Edmund Davies ,  Robert Tornoe

IPC分类号： H05H13/00

CPC分类号： H01J25/04 ,  H01J23/005 ,  H01J2223/005 ,  H01J2225/04

摘要： An inductive output tube (IOT) operates in a frequency range above 1000 MHz. An output window may be provided to separate a vacuum portion of the IOT from an atmospheric pressure portion of the IOT, the output window being surrounded by a cooling air manifold, the manifold including an air input port and a plurality of apertures permitting cooling air to move from the port, through the manifold and into the atmospheric pressure portion of the IOT. The output cavity may include a liquid coolant input port; a lower circular coolant channel coupled to receive liquid coolant from the liquid coolant input port; a vertical coolant channel coupled to receive liquid coolant from the lower circular coolant channel; an upper circular coolant channel coupled to receive liquid coolant from the vertical coolant channel; and a liquid coolant exhaust port coupled to receive liquid coolant from the upper circular coolant channel.