公开(公告)号：US20210388382A1

公开(公告)日：2021-12-16

申请号：US17053733

申请日：2019-05-08

Applicant: Neuracle Science Co., Ltd. ,  Neuracle Genetics

Inventor： Jong-Mook KIM ,  Dong Sik KIM ,  Juwon SHIM ,  Soon-gu KWON

IPC: C12N15/86 ,  C07K16/24

Abstract: The present disclosure provides adeno-associated vims (AAV) vectors and uses thereof. In certain embodiments, the AAV vectors comprise a nucleic acid that encodes an antagonist against a family with sequence similarity 19, member A5 (FAM19A5) protein, e.g., anti-FAM19A5 antibody, e.g., anti-FAM19A5 scFv.

公开(公告)号：US20200223914A1

公开(公告)日：2020-07-16

申请号：US16626625

申请日：2018-06-27

Applicant: Neuracle Science Co., Ltd. ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Bongcheol KIM ,  Eun Bee CHO ,  Dong Sik KIM ,  Jae-Keun LEE ,  Soon-gu KWON ,  Jae Young SEONG ,  Juwon SHIM ,  Tae Woo KIM ,  Shin-hyuk KANG

IPC: C07K16/24 ,  A61P35/00 ,  C07K16/30

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to promote a blood vessel normalization and treat a disease (e.g., cancer) in a subject in need thereof, e.g., by promoting a blood vessel normalization.

公开(公告)号：US20230348584A1

公开(公告)日：2023-11-02

申请号：US18158259

申请日：2023-01-23

Applicant: Neuracle Science Co., Ltd.

Inventor： Bongcheol KIM ,  Eun Bee CHO ,  Dong Sik KIM ,  Jae-Keun LEE ,  Soon-gu KWON ,  Jae Young SEONG ,  Juwon SHIM ,  Tae Woo KIM ,  Shin-hyuk KANG

IPC: C07K16/24 ,  A61P35/00 ,  C07K16/30

CPC classification number: C07K16/24 ,  A61P35/00 ,  C07K16/30 ,  A61K45/06

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to promote a blood vessel normalization and treat a disease (e.g., cancer) in a subject in need thereof, e.g., by promoting a blood vessel normalization.

公开(公告)号：US20220064277A1

公开(公告)日：2022-03-03

申请号：US17418681

申请日：2019-12-26

Applicant: NEURACLE SCIENCE CO., LTD.

Inventor： Bongcheol KIM ,  Dong Sik KIM ,  Jae-Keun LEE ,  Juwon SHIM

IPC: C07K16/24 ,  A61P9/10

Abstract: The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat an atherosclerosis in a subject in need thereof.