公开(公告)号：US20250092036A1

公开(公告)日：2025-03-20

申请号：US18800559

申请日：2024-08-12

Applicant: Novartis AG

Inventor： Erich W. BAUM ,  Thomas A. DINEEN, JR. ,  Jonathan Edward HEMPEL ,  Matthew James HESSE ,  Robert KOENIG ,  Matthew James LAMARCHE ,  Jay Francis LARROW ,  Ruowei MO ,  Henrik MOEBITZ ,  Rukundo NTAGANDA ,  Keith Bruce PFISTER ,  Martin SENDZIK ,  Colin Keith SKEPPER ,  Joseph WZOREK, JR. ,  Frédéric ZECRI

IPC: C07D471/04 ,  A61K31/454 ,  A61K31/4545 ,  A61P35/00 ,  C07D401/06 ,  C07D405/14 ,  C07D491/052

Abstract: The invention relates to compounds which modulate the activity of ERK. The present invention also relates to processes for the preparation of said compounds, pharmaceutical compositions comprising said compounds, and use of said compounds in the treatment of conditions, diseases and disorders mediated by ERK.

公开(公告)号：US20180318311A1

公开(公告)日：2018-11-08

申请号：US15971156

申请日：2018-05-04

Applicant: Novartis AG

Inventor： Guillaume LAPOINTE ,  Wosenu MERGO ,  Heinz Ernst MOSER ,  Alexey RIVKIN ,  Colin Keith SKEPPER ,  Sarah Louise Williams

IPC: A61K31/5383 ,  A61P31/04

CPC classification number: A61K31/5383 ,  A61K31/407 ,  A61K31/473 ,  A61P31/04 ,  C07D455/04 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof that are useful as antibacterial agents. The compounds are useful as inhibitors of bacterial gyrase activity and of bacterial infections, and have the structure of Formula (I): as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

公开(公告)号：US20170217897A1

公开(公告)日：2017-08-03

申请号：US15500870

申请日：2015-08-03

Applicant: Zhigan JIANG ,  Jianhua XIA ,  Haiying HE ,  NOVARTIS AG

Inventor： Javier de Vicente FIDALGO ,  Haiying HE ,  Cheng HU ,  Zhigan JIANG ,  Xiaolin LI ,  Peichao LU ,  Wosenu MERGO ,  Daniel MUTNICK ,  Folkert RECK ,  Alexey RIVKIN ,  Colin Keith SKEPPER ,  Xiaojing Michael WANG ,  Jianhua XIA ,  Yongjin XU

IPC: C07D215/38 ,  A61K31/4709 ,  A61K31/496 ,  C07D401/14 ,  C07D413/14 ,  C07D419/14 ,  C07D405/14 ,  C07D471/04 ,  C07D498/10 ,  A61K31/5377 ,  A61K31/5386 ,  C07D487/10 ,  C07D471/10 ,  A61K45/06 ,  C07D401/04

CPC classification number: C07D215/38 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5386 ,  A61K45/06 ,  C07D215/22 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D419/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10 ,  C07D498/10 ,  Y02A50/406 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

Abstract: This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.