公开(公告)号：US11708366B2

公开(公告)日：2023-07-25

申请号：US17400458

申请日：2021-08-12

Applicant: Novartis AG

Inventor： Mallesh Bushaboina ,  Xin Chen ,  Atwood Kim Cheung ,  Andrew James Culshaw ,  Timothy Brian Hurley ,  Nancy Labbe-Giguere ,  Wolfgang Miltz ,  David Orain ,  Tajesh Patel ,  Srinivasan Rajagopalan ,  Till Roehn ,  David Andrew Sandham ,  Gebhard Thoma ,  Ritesh Bhanudasji Tichkule ,  Rudolf Wälchli

IPC: C07D471/10 ,  A61K31/438 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D471/10 ,  A61K45/06 ,  C07D519/00

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;




wherein R1 R2, R4 and X1 are defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US12157737B2

公开(公告)日：2024-12-03

申请号：US18319585

申请日：2023-05-18

Applicant: NOVARTIS AG

Inventor： Mallesh Bushaboina ,  Xin Chen ,  Atwood Kim Cheung ,  Andrew James Culshaw ,  Timothy Brian Hurley ,  Nancy Labbe-Giguere ,  Wolfgang Miltz ,  David Orain ,  Tajesh Patel ,  Srinivasan Rajagopalan ,  Till Roehn ,  David Andrew Sandham ,  Gebhard Thoma ,  Ritesh Bhanudasji Tichkule ,  Rudolf Wälchli

IPC: A61K31/438 ,  A61K31/506 ,  A61K45/06 ,  C07D471/10 ,  C07D519/00

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein R1 R2, R4 and X1 are defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US09650377B2

公开(公告)日：2017-05-16

申请号：US15042924

申请日：2016-02-12

Applicant: Novartis AG

Inventor： Dirk Behnke ,  David Carcache ,  Peter Ertl ,  Manuel Koller ,  David Orain

IPC: A61K31/551 ,  C07D471/04 ,  C07D471/14 ,  A61K45/06 ,  C07D498/04

CPC classification number: C07D471/04 ,  A61K31/551 ,  A61K45/06 ,  C07D471/14 ,  C07D498/04 ,  C07D519/00

Abstract: The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.