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公开(公告)号：US12157737B2
公开(公告)日：2024-12-03
申请号：US18319585
申请日：2023-05-18
Applicant: NOVARTIS AG
Inventor： Mallesh Bushaboina , Xin Chen , Atwood Kim Cheung , Andrew James Culshaw , Timothy Brian Hurley , Nancy Labbe-Giguere , Wolfgang Miltz , David Orain , Tajesh Patel , Srinivasan Rajagopalan , Till Roehn , David Andrew Sandham , Gebhard Thoma , Ritesh Bhanudasji Tichkule , Rudolf Wälchli
IPC: A61K31/438 , A61K31/506 , A61K45/06 , C07D471/10 , C07D519/00
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein R1 R2, R4 and X1 are defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US11053218B2
公开(公告)日：2021-07-06
申请号：US16835938
申请日：2020-03-31
Applicant: Novartis AG
Inventor： Rohan Eric John Beckwith , Simone Bonazzi , Artiom Cernijenko , Aleem Fazal , Ritesh Bhanudasji Tichkule , Michael Scott Visser
IPC: C07D401/14 , A61K31/4412 , C07D401/04 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04 , C07D513/04 , A61P35/00
Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.
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公开(公告)号：US10414755B2
公开(公告)日：2019-09-17
申请号：US16108713
申请日：2018-08-22
Applicant: Novartis AG
Inventor： Rohan Eric John Beckwith , Simone Bonazzi , Artiom Cernijenko , Aleem Fazal , Ritesh Bhanudasji Tichkule , Michael Scott Visser
IPC: C07D401/14 , A61K31/4412 , A61P35/00 , C07D413/14 , C07D401/04 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04 , C07D513/04
Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.
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公开(公告)号：US11708366B2
公开(公告)日：2023-07-25
申请号：US17400458
申请日：2021-08-12
Applicant: Novartis AG
Inventor： Mallesh Bushaboina , Xin Chen , Atwood Kim Cheung , Andrew James Culshaw , Timothy Brian Hurley , Nancy Labbe-Giguere , Wolfgang Miltz , David Orain , Tajesh Patel , Srinivasan Rajagopalan , Till Roehn , David Andrew Sandham , Gebhard Thoma , Ritesh Bhanudasji Tichkule , Rudolf Wälchli
IPC: C07D471/10 , A61K31/438 , A61K45/06 , C07D519/00
CPC classification number: C07D471/10 , A61K45/06 , C07D519/00
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;
wherein R1 R2, R4 and X1 are defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.-
公开(公告)号：US20180369386A1
公开(公告)日：2018-12-27
申请号：US16115883
申请日：2018-08-29
Applicant: Novartis AG
Inventor： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC: A61K47/18 , C07C229/14 , A61K9/127 , A61K9/51 , C12N15/113 , C07D317/28 , C07D295/096 , C07D213/79 , C07D213/69 , C07D205/04 , C07C235/42 , A61K9/00 , C07C229/12 , C07C219/06 , C07C217/58 , A61K47/22 , A61K38/22 , A61K31/713 , A61K48/00
Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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Patent Agency Ranking
公开(公告)号：US10792361B2
公开(公告)日：2020-10-06
申请号：US16115883
申请日：2018-08-29
Applicant: Novartis AG
Inventor： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC: A61K47/18 , A61K9/127 , A61K9/51 , A61K31/713 , C07C217/58 , C07C219/06 , C07C229/12 , C07D317/28 , C07D295/096 , A61K9/00 , A61K38/22 , A61K47/22 , C07C229/14 , C07C235/42 , C07D205/04 , C07D213/69 , C07D213/79 , C12N15/113 , A61K48/00
Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US10729775B2
公开(公告)日：2020-08-04
申请号：US16021193
申请日：2018-06-28
Applicant: Novartis AG
Inventor： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC: A61K47/18 , C12N15/113 , A61K47/22 , C07D213/79 , C07D317/24 , C07D317/28 , C07D205/04 , C07D295/096 , C07D213/69 , A61K9/127 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08
Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US10647701B2
公开(公告)日：2020-05-12
申请号：US16532118
申请日：2019-08-05
Applicant: Novartis AG
Inventor： Rohan Eric John Beckwith , Simone Bonazzi , Artiom Cernijenko , Ritesh Bhanudasji Tichkule , Michael Scott Visser
IPC: C07D401/14 , A61K31/44 , C07D401/04 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04 , C07D513/04 , A61P35/00
Abstract: The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.
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公开(公告)号：US10124065B2
公开(公告)日：2018-11-13
申请号：US14779939
申请日：2014-03-06
Applicant: Novartis AG
Inventor： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC: C07C211/00 , A61K9/00 , C07C217/00 , A61K47/22 , A61K47/18 , C07C217/58 , C07C219/06 , C07C229/12 , C07D317/28 , C07D295/096 , A61K9/127 , A61K9/51 , A61K31/713 , A61K38/22 , C07C229/14 , C07C235/42 , C07D205/04 , C07D213/69 , C07D213/79 , C12N15/113 , A61K48/00
Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号：US20180296677A1
公开(公告)日：2018-10-18
申请号：US16021193
申请日：2018-06-28
Applicant: Novartis AG
Inventor： Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC: A61K47/18 , C07C235/46 , A61K9/127 , C12N15/113 , C07D317/28 , C07D317/24 , C07D295/096 , C07D213/79 , C07D213/69 , C07D205/04 , C07C237/08 , C07C229/12 , C07C219/28 , C07C219/22 , C07C217/62 , C07C217/60 , C07C217/58 , A61K47/22
Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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