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1.发明授权1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions 有权其中的1,4-二取代哒嗪类似物和用于治疗SMN缺陷相关病症的方法公开(公告)号：US09545404B2
公开(公告)日：2017-01-17
申请号：US14242282
申请日：2014-04-01
Applicant: NOVARTIS AG
Inventor： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
IPC: C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/04 , A61K31/551 , A61K31/5377 , A61K31/501 , A61K31/502 , A61K31/506 , A61K45/06 , C07D237/20 , C07D401/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/08 , C07D487/10
CPC classification number: A61K31/501 , A61K31/41 , A61K31/427 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/06 , C07D237/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10
Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Abstract translation: 本发明提供式I化合物或其药学上可接受的盐; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US12157737B2
公开(公告)日：2024-12-03
申请号：US18319585
申请日：2023-05-18
Applicant: NOVARTIS AG
Inventor： Mallesh Bushaboina , Xin Chen , Atwood Kim Cheung , Andrew James Culshaw , Timothy Brian Hurley , Nancy Labbe-Giguere , Wolfgang Miltz , David Orain , Tajesh Patel , Srinivasan Rajagopalan , Till Roehn , David Andrew Sandham , Gebhard Thoma , Ritesh Bhanudasji Tichkule , Rudolf Wälchli
IPC: A61K31/438 , A61K31/506 , A61K45/06 , C07D471/10 , C07D519/00
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein R1 R2, R4 and X1 are defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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![4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO[4,3-D]PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS](/abs-image/US/2015/07/30/US20150210709A1/abs.jpg.150x150.jpg)
3.发明申请4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO[4,3-D]PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS 有权4-OXO-3,5,7,8-四氢-4H-吡喃[4,3-D]吡啶类化合物，用作盐酸盐抑制剂公开(公告)号：US20150210709A1
公开(公告)日：2015-07-30
申请号：US14154170
申请日：2012-07-13
Applicant: Novartis AG
Inventor： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Michael David Shultz , Ronald Charles Tomlinson
IPC: C07D491/052
CPC classification number: C07D491/052 , A61K31/519
Abstract: The present invention provides for compounds of formula (I) wherein R1 and R2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
Abstract translation: 本发明提供式（I）化合物，其中R 1和R 2在本文中定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
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公开(公告)号：US12084442B2
公开(公告)日：2024-09-10
申请号：US18057505
申请日：2022-11-21
Applicant: Novartis AG
Inventor： Atwood Kim Cheung , Donglei Liu , Stefan Peukert , Heng Ge , Yu Gai , Xingjuan Chang
IPC: A61K45/06 , C07D471/04
CPC classification number: C07D471/04 , A61K45/06
Abstract: The invention relates to a compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein A, R1 and R3 are as described herein, as well as compositions and methods of using such compounds.-
公开(公告)号：US11672799B2
公开(公告)日：2023-06-13
申请号：US16259441
申请日：2019-01-28
Applicant: Novartis AG
Inventor： Atwood Kim Cheung , Natalie Dales , Timothy Brian Hurley
IPC: A61K31/501 , C07D401/14 , C07D401/04 , A61K31/502 , A61K31/517 , C07D487/10 , C07D405/14 , C07D413/14 , C07D487/04 , A61K31/5377
CPC classification number: A61K31/501 , A61K31/502 , A61K31/517 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D487/10
Abstract: The present invention provides a compound of formula IA or a pharmaceutically acceptable salt thereof;
a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.-
Patent Agency Ranking
公开(公告)号：US11229648B2
公开(公告)日：2022-01-25
申请号：US16934787
申请日：2020-07-21
Applicant: Novartis AG
Inventor： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Brian Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
IPC: C07D401/04 , C07D471/10 , C07D487/08 , C07D487/10 , A61K31/501 , A61P21/00 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/20 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , A61K31/41 , A61K31/427 , C07D237/06
Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US12129246B1
公开(公告)日：2024-10-29
申请号：US18589841
申请日：2024-02-28
Applicant: Novartis AG
Inventor： Daniela Angst , Philippe Bolduc , Matthew William Carson , Atwood Kim Cheung , Véronique Darsigny , Xiang Gao , Viktor Hornak , Keith Jendza , Rajesh Karki , Ajay Kumar Lal , Gang Liu , Justin Yik Ching Mao , Jeffrey M. McKenna , Erik Meredith , Muneto Mogi , Vivek Rauniyar , Liansheng Su , Ritesh Tichkule , Shuangxi Wang , Chun Zhang , Liang Zhao , Rui Zheng
IPC: C07D403/14 , A61K31/517 , A61K31/55 , A61K45/06 , C07D239/95 , C07D401/12 , C07D401/14
CPC classification number: C07D403/14 , A61K31/517 , A61K31/55 , A61K45/06 , C07D239/95 , C07D401/12 , C07D401/14
Abstract: The disclosure relates to a compound of Formula (I):
or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.-
公开(公告)号：US10195196B2
公开(公告)日：2019-02-05
申请号：US15364248
申请日：2016-11-29
Applicant: NOVARTIS AG
Inventor： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
IPC: A61K31/501 , C07D401/14 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/20 , C07D401/04 , C07D401/12 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , A61K31/41 , A61K31/427 , C07D237/06
Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US11708366B2
公开(公告)日：2023-07-25
申请号：US17400458
申请日：2021-08-12
Applicant: Novartis AG
Inventor： Mallesh Bushaboina , Xin Chen , Atwood Kim Cheung , Andrew James Culshaw , Timothy Brian Hurley , Nancy Labbe-Giguere , Wolfgang Miltz , David Orain , Tajesh Patel , Srinivasan Rajagopalan , Till Roehn , David Andrew Sandham , Gebhard Thoma , Ritesh Bhanudasji Tichkule , Rudolf Wälchli
IPC: C07D471/10 , A61K31/438 , A61K45/06 , C07D519/00
CPC classification number: C07D471/10 , A61K45/06 , C07D519/00
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;
wherein R1 R2, R4 and X1 are defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.-
10.发明授权公开(公告)号：US10758533B2
公开(公告)日：2020-09-01
申请号：US16237907
申请日：2019-01-02
Applicant: Novartis AG
Inventor： Atwood Kim Cheung , Donovan Noel Chin , Natalie Dales , Aleem Fazal , Timothy Brian Hurley , John Kerrigan , Gary O'Brien , Lei Shu , Robert Sun , Moo Je Sung
IPC: C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D237/20 , C07D403/10 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , A61K31/41 , A61K31/427 , C07D237/06
Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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