公开(公告)号：US20170266189A1

公开(公告)日：2017-09-21

申请号：US15478778

申请日：2017-04-04

Applicant: NOVARTIS AG

Inventor： Edgar JACOBY ,  Juergen REINHARDT ,  Niko SCHMIEDEBERG ,  Carsten SPANKA

IPC: A61K31/519 ,  C07D471/14 ,  C07D471/04

CPC classification number: A61K31/519 ,  C07D471/04 ,  C07D471/14

Abstract: The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

公开(公告)号：US20130281473A1

公开(公告)日：2013-10-24

申请号：US13778910

申请日：2013-02-27

Applicant: Novartis AG

Inventor： Joerg BERGHAUSEN ,  Nicole BUSCHMANN ,  Pascal FURET ,  Francois GESSIER ,  Joanna HERGOVICH LISZTWAN ,  Philipp HOLZER ,  Edgar JACOBY ,  Joerg KALLEN ,  Keiichi MASUYA ,  Carole PISSOT SOLDERMANN ,  Haixia REN ,  Stefan STUTZ

IPC: C07D239/82

CPC classification number: C07D239/82 ,  C07D217/24 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

Abstract translation: 本发明涉及式（I）的取代的含氮双环杂环，其中Z是CH 2或N-R 4，X，R 1，R 2，R 4，R 6，R 7和n如说明书中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。