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公开(公告)号:US20130281473A1
公开(公告)日:2013-10-24
申请号:US13778910
申请日:2013-02-27
Applicant: Novartis AG
Inventor: Joerg BERGHAUSEN , Nicole BUSCHMANN , Pascal FURET , Francois GESSIER , Joanna HERGOVICH LISZTWAN , Philipp HOLZER , Edgar JACOBY , Joerg KALLEN , Keiichi MASUYA , Carole PISSOT SOLDERMANN , Haixia REN , Stefan STUTZ
IPC: C07D239/82
CPC classification number: C07D239/82 , C07D217/24 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
Abstract: The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
Abstract translation: 本发明涉及式(I)的取代的含氮双环杂环,其中Z是CH 2或N-R 4,X,R 1,R 2,R 4,R 6,R 7和n如说明书中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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公开(公告)号:US20210299100A1
公开(公告)日:2021-09-30
申请号:US17201268
申请日:2021-03-15
Applicant: Novartis AG
Inventor: Vincent BORDAS , Cara BROCKLEHURST , Patrick CHENE , Zhongbo FEI , Pascal FURET , Vito GUAGNANO , Patricia IMBACH-WEESE , Joerg KALLEN , Mickael LE DOUGET , Jialiang LI , Wei LI , Edwige Liliane Jeanne LORTHIOIS , Joseph McKENNA , Bahaa SALEM , Tobias SCHMELZLE , Holger SELLNER , Nicolas SOLDERMANN , Markus VOEGTLE , Markus WARTMANN
IPC: A61K31/4155 , C07D307/81 , C07D405/12 , A61K31/343 , A61K31/443 , A61K31/426 , C07D417/04 , C07D407/04 , A61K31/357 , C07D405/04 , A61K31/403 , A61K31/4525 , A61K31/351 , C07D407/12 , A61K31/506 , A61K31/41 , A61K31/4025 , A61K31/4439 , C07D405/14 , A61P35/00
Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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公开(公告)号:US20140011798A1
公开(公告)日:2014-01-09
申请号:US13748790
申请日:2013-01-24
Applicant: NOVARTIS AG
Inventor: Pascal FURET , Vito GUAGNANO , Philipp HOLZER , Joerg KALLEN , Lv LIAO , Robert MAH , Liang MAO , Keiichi MASUYA , Achim SCHLAPBACH , Stefan STUTZ , Andrea VAUPEL
IPC: C07D487/04 , A61K31/4439 , A61K45/06 , A61K31/5377 , A61K31/501 , A61K31/541 , A61K31/4188 , A61K31/506
CPC classification number: C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
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公开(公告)号:US20240382457A1
公开(公告)日:2024-11-21
申请号:US18776928
申请日:2024-07-18
Applicant: Novartis AG
Inventor: Vincent BORDAS , Cara BROCKLEHURST , Patrick CHENE , Pascal FURET , Vito GUAGNANO , Patricia IMBACH-WEESE , Joerg KALLEN , Mickael LE DOUGET , Edwige Liliane Jeanne LORTHIOIS , Joseph MCKENNA , Bahaa SALEM , Tobias SCHMELZLE , Holger SELLNER , Nicolas SOLDERMANN , Markus VOEGTLE , Markus WARTMANN
IPC: A61K31/4155 , A61K31/343 , A61K31/351 , A61K31/357 , A61K31/4025 , A61K31/403 , A61K31/41 , A61K31/426 , A61K31/443 , A61K31/4439 , A61K31/4525 , A61K31/506 , A61P35/00 , C07D307/81 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D417/04
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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公开(公告)号:US20140343084A1
公开(公告)日:2014-11-20
申请号:US14327639
申请日:2014-07-10
Applicant: Novartis AG
Inventor: Pascal FURET , Vito GUAGNANO , Philipp HOLZER , Joerg KALLEN , Lv LIAO , Robert MAH , Liang MAO , Keiichi MASUYA , Achim SCHLAPBACH , Stefan STUTZ , Andrea VAUPEL
IPC: C07D487/04
CPC classification number: C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
Abstract translation: 本发明涉及式(I)化合物:如本文所述,包含这些化合物的药物制剂,用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法,以及 包含这些化合物的组合。
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