公开(公告)号：US20130281473A1

公开(公告)日：2013-10-24

申请号：US13778910

申请日：2013-02-27

Applicant: Novartis AG

Inventor： Joerg BERGHAUSEN ,  Nicole BUSCHMANN ,  Pascal FURET ,  Francois GESSIER ,  Joanna HERGOVICH LISZTWAN ,  Philipp HOLZER ,  Edgar JACOBY ,  Joerg KALLEN ,  Keiichi MASUYA ,  Carole PISSOT SOLDERMANN ,  Haixia REN ,  Stefan STUTZ

IPC: C07D239/82

CPC classification number: C07D239/82 ,  C07D217/24 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

Abstract translation: 本发明涉及式（I）的取代的含氮双环杂环，其中Z是CH 2或N-R 4，X，R 1，R 2，R 4，R 6，R 7和n如说明书中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。

公开(公告)号：US20140343084A1

公开(公告)日：2014-11-20

申请号：US14327639

申请日：2014-07-10

Applicant: Novartis AG

Inventor： Pascal FURET ,  Vito GUAGNANO ,  Philipp HOLZER ,  Joerg KALLEN ,  Lv LIAO ,  Robert MAH ,  Liang MAO ,  Keiichi MASUYA ,  Achim SCHLAPBACH ,  Stefan STUTZ ,  Andrea VAUPEL

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06

Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

Abstract translation: 本发明涉及式（I）化合物：如本文所述，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法，以及 包含这些化合物的组合。

公开(公告)号：US20140011798A1

公开(公告)日：2014-01-09

申请号：US13748790

申请日：2013-01-24

Applicant: NOVARTIS AG

Inventor： Pascal FURET ,  Vito GUAGNANO ,  Philipp HOLZER ,  Joerg KALLEN ,  Lv LIAO ,  Robert MAH ,  Liang MAO ,  Keiichi MASUYA ,  Achim SCHLAPBACH ,  Stefan STUTZ ,  Andrea VAUPEL

IPC: C07D487/04 ,  A61K31/4439 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/541 ,  A61K31/4188 ,  A61K31/506

CPC classification number: C07D487/04 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06

Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.