公开(公告)号：US20210139585A1

公开(公告)日：2021-05-13

申请号：US16877878

申请日：2020-05-19

Applicant: Novartis AG

Inventor： Brian Granda ,  Amy Rayo ,  Connie Hong ,  Dattananda Chelur ,  Haihui Lu ,  Regis Cebe ,  Sunyoung Jang

IPC: C07K16/28 ,  C07K14/47 ,  C12N15/63 ,  A61P35/00

Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.

公开(公告)号：US20220396631A1

公开(公告)日：2022-12-15

申请号：US17595637

申请日：2020-05-19

Applicant: Lu HUANG ,  Brian GRANDA ,  John BLANKENSHIP ,  Aida ABUJOUB ,  Tony FLEMING ,  Haihui LU ,  Connie HONG ,  Brian HOLMBERG ,  Novartis AG

Inventor： Brian Walter Granda ,  John Blankenship ,  Aida Abujoub ,  Tony Fleming ,  Lu Huang ,  Connie Hong ,  Brian Holmberg ,  Haihui Lu

IPC: C07K16/28

Abstract: The present disclosure provides multispecific binding molecules that specifically bind to BCMA, a component of a human T-cell receptor complex and either CD2 or a tumor associated antigen, conjugates comprising the multispecific binding molecules, and pharmaceutical compositions comprising the multispecific binding molecules and the conjugates The disclosure further provides methods of using the multispecific binding molecules to treat disease and disorders associated with expression of BCMA. The disclosure yet further provides recombinant host cells engineered to express the multispecific binding molecules and methods of producing the multispecific binding molecules by culturing the host cells under conditions in which the multispecific binding molecules are expressed.

公开(公告)号：US12275795B2

公开(公告)日：2025-04-15

申请号：US17934064

申请日：2022-09-21

Applicant: NOVARTIS AG

Inventor： Aida Abujoub ,  John Blankenship ,  Tony Fleming ,  Brian Holmberg ,  Connie Hong ,  Lu Huang ,  Haihui Lu

IPC: C07K16/28 ,  A61K39/395 ,  A61K47/68 ,  A61P35/00 ,  C07K14/715 ,  C07K14/725 ,  C07K14/735 ,  C07K16/30 ,  C07K16/46 ,  C12N5/10 ,  C12N15/63 ,  A61K39/00

Abstract: The present disclosure provides BCMA binding molecules that specifically bind to human BCMA, conjugates comprising the BCMA binding molecules, and pharmaceutical compositions comprising the BCMA binding molecules and the conjugates. The disclosure further provides methods of using the BCMA binding molecules to treat cancers that express cell surface BCMA. The disclosure yet further provides recombinant host cells engineered to express the BCMA binding molecules and methods of producing the BCMA binding molecules by culturing the host cells under conditions in which the BCMA binding molecules are expressed.

公开(公告)号：US12221481B2

公开(公告)日：2025-02-11

申请号：US16877878

申请日：2020-05-19

Applicant: Novartis AG

Inventor： Brian Granda ,  Amy Rayo ,  Connie Hong ,  Dattananda Chelur ,  Haihui Lu ,  Regis Cebe ,  Sunyoung Jang

IPC: C07K16/30 ,  A61P35/00 ,  C07K14/47 ,  C07K16/28 ,  C12N15/63 ,  A61K39/00

Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.

公开(公告)号：US11492409B2

公开(公告)日：2022-11-08

申请号：US16426914

申请日：2019-05-30

Applicant: NOVARTIS AG

Inventor： Aida Abujoub ,  John Blankenship ,  Tony Fleming ,  Brian Holmberg ,  Connie Hong ,  Lu Huang ,  Haihui Lu

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  C07K14/715 ,  C07K14/725 ,  C07K14/735 ,  A61K39/395 ,  A61K47/68 ,  A61P35/00 ,  A61K39/00

Abstract: The present disclosure provides BCMA binding molecules that specifically bind to human BCMA, conjugates comprising the BCMA binding molecules, and pharmaceutical compositions comprising the BCMA binding molecules and the conjugates. The disclosure further provides methods of using the BCMA binding molecules to treat cancers that express cell surface BCMA. The disclosure yet further provides recombinant host cells engineered to express the BCMA binding molecules and methods of producing the BCMA binding molecules by culturing the host cells under conditions in which the BCMA binding molecules are expressed.

公开(公告)号：US20200179511A1

公开(公告)日：2020-06-11

申请号：US16608515

申请日：2018-04-27

Applicant: Michael Daley ,  Novartis AG

Inventor： Michael Daley ,  Haihui Lu

IPC: A61K39/395 ,  C07K16/28 ,  A61P35/00

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to a method of administering a BCMA-targeting agent which is an anti-BCMA antibody molecule or a recombinant non-antibody protein that binds to BCMA, and a gamma secretase inhibitor.