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    CD19 binding molecules and uses thereof
    2.
    发明授权
    CD19 binding molecules and uses thereof 有权

    公开(公告)号：US12221481B2

    公开(公告)日：2025-02-11

    申请号：US16877878

    申请日：2020-05-19

    Applicant: Novartis AG

    Inventor： Brian Granda ,  Amy Rayo ,  Connie Hong ,  Dattananda Chelur ,  Haihui Lu ,  Regis Cebe ,  Sunyoung Jang

    IPC: C07K16/30 ,  A61P35/00 ,  C07K14/47 ,  C07K16/28 ,  C12N15/63 ,  A61K39/00

    Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.

    Variant CD58 domains and uses thereof
    3.
    发明授权
    Variant CD58 domains and uses thereof 有权

    公开(公告)号：US12037378B2

    公开(公告)日：2024-07-16

    申请号：US17612993

    申请日：2020-05-19

    Applicant: NOVARTIS AG

    Inventor： Barbara Brannetti ,  Dattananda Chelur ,  Brian Granda ,  Connie Hong

    IPC: C07K14/705

    CPC classification number: C07K14/70528

    Abstract: The present disclosure provides CD2 binding molecules that specifically bind to CD2, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD2 binding molecules, and pharmaceutical compositions comprising the CD2 binding molecules and the conjugates. The disclosure further provides methods of using the CD2 binding molecules to modulate CD2 signaling in order to treat a variety of immune (e.g., autoimmune), inflammatory and proliferative disorders. The disclosure yet further provides recombinant host cells engineered to express the CD2 binding molecules and methods of producing the CD2 binding molecules by culturing the host cells under conditions in which the CD2 binding molecules are expressed.

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