公开(公告)号：US20240183076A1

公开(公告)日：2024-06-06

申请号：US18550004

申请日：2022-03-09

Applicant: Novartis AG

Inventor： Asitha Adrian ABEYWARDANE ,  Tushar Dattu APSUNDE ,  Gianluca Nicolas ETIENNE ,  Alessia GAMBARDELLA ,  James Kevin MAINQUIST ,  Andrew J. MEYER ,  Brian MINIE ,  Steven PAULA ,  Dwayne A. L. VICKERS ,  Ken YAMADA

IPC: C40B40/06 ,  B01L3/00 ,  C08L87/00

CPC classification number: C40B40/06 ,  B01L3/502761 ,  B01L3/502784 ,  C08L87/005 ,  B01L2200/0652 ,  B01L2300/0829 ,  B01L2400/0415

Abstract: The present disclosure generally relates to compositions, methods, sorters, systems, devices and uses for screening for bioactive substances in emulsion droplets. In some embodiments, the compositions are a continuous phase formulation for stable emulsions, In some embodiments, the methods are for preparing a monodisperse polyethylene glycol acrylamide (PEGA) co-polymer resin, or for preparing a core-shell bead. In some embodiments, the systems and devices include a sorter, comprising an inlet channel, first and second outlet channels meeting the inlet channel at a junction, and first and second electrodes proximate respective first and second sides of the junction sorter. In some embodiments, the systems and devices include a sorter, comprising a microwell array plate configured to host one microdroplet per microwell, a fluorescence microscope, an imager configured to automatically image assay droplets and identify desired droplets, and an automated microcapillary-based droplet sampling device configured to continuously deposit desired droplets to hit wells.