公开(公告)号：US20210220346A1

公开(公告)日：2021-07-22

申请号：US17055647

申请日：2019-05-15

申请人： Aegis Therapeutics LLC ,  Opiant Pharmaceuticals, Inc.

发明人： Roger Crystal ,  Phil Skolnick ,  Edward T. Maggio

IPC分类号： A61K31/485 ,  A61K47/18 ,  A61K47/26 ,  A61K9/00 ,  A61M11/00 ,  A61M15/08

摘要： Formulations and methods for the preventative treatment of incidental opioid overdose comprising the intranasal (IN) administration of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.

公开(公告)号：US20200060967A1

公开(公告)日：2020-02-27

申请号：US16461354

申请日：2017-11-09

申请人： Opiant Pharmaceuticals, Inc. ,  Aegis Therapeutics, LLC

发明人： Roger Crystal ,  Edward T. Maggio

IPC分类号： A61K9/00 ,  A61K31/485 ,  A61K47/18 ,  A61K47/26 ,  A61K47/02 ,  A61P25/36

摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.

公开(公告)号：US09629965B2

公开(公告)日：2017-04-25

申请号：US15335145

申请日：2016-10-26

申请人： Opiant Pharmaceuticals, Inc.

发明人： Roger Crystal ,  Michael Brenner Weiss

IPC分类号： A61M31/00 ,  A61M5/00 ,  A61F13/00 ,  A61K31/56 ,  A61M11/00 ,  A61K9/00 ,  A61K31/485 ,  A61K47/02 ,  A61K47/18 ,  A61K9/08 ,  A61M15/08

CPC分类号： A61K31/485 ,  A61K9/0043 ,  A61K9/08 ,  A61K47/02 ,  A61K47/18 ,  A61K47/183 ,  A61K47/186 ,  A61M11/001 ,  A61M11/006 ,  A61M15/08 ,  A61M31/00

摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.

公开(公告)号：US11458091B2

公开(公告)日：2022-10-04

申请号：US16461354

申请日：2017-11-09

申请人： Opiant Pharmaceuticals, Inc. ,  Aegis Therapeutics, LLC

发明人： Roger Crystal ,  Edward T. Maggio

IPC分类号： A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A61K9/00 ,  A61P25/36 ,  A61K31/485 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26

摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.

公开(公告)号：US20210401827A1

公开(公告)日：2021-12-30

申请号：US17291979

申请日：2019-11-07

申请人： OPIANT PHARMACEUTICALS, INC.

发明人： Roger Crystal ,  Phil Skolnick

IPC分类号： A61K31/485 ,  A61K9/00 ,  A61P25/36 ,  A61K9/08 ,  A61K47/02

摘要： Methods, pharmaceutical formulations and devices for the preventative treatment of incidental opioid overdose comprising the intramuscular or subcutaneous administration using an auto-injection device of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.

公开(公告)号：US20230225961A1

公开(公告)日：2023-07-20

申请号：US18174858

申请日：2023-02-27

申请人： Opiant Pharmaceuticals, Inc.

发明人： Roger Crystal ,  Phil Skolnick ,  Edward T. Maggio

IPC分类号： A61K9/00 ,  A61P25/36 ,  A61K9/08 ,  A61K31/485 ,  A61K47/02

CPC分类号： A61K9/0019 ,  A61P25/36 ,  A61K9/08 ,  A61K31/485 ,  A61K47/02

摘要： Methods, pharmaceutical formulations and devices for the preventative treatment of incidental opioid overdose comprising the intramuscular or subcutaneous administration using an auto-injection device of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.

公开(公告)号：US20230055547A1

公开(公告)日：2023-02-23

申请号：US17881306

申请日：2022-08-04

申请人： Opiant Pharmaceuticals, Inc.

发明人： Phil Skolnick ,  Mark Ellison ,  Roger Crystal

IPC分类号： A61K9/00 ,  A61K31/485 ,  A61P25/36 ,  A61K47/18 ,  A61K47/26

摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.

公开(公告)号：US20190209464A1

公开(公告)日：2019-07-11

申请号：US16311944

申请日：2017-06-26

申请人： Opiant Pharmaceuticals, Inc. ,  Aegis Therapeutics ,LLC

发明人： Roger Crystal ,  Arvind Agrawal ,  Edward T. Maggio

IPC分类号： A61K9/00 ,  A61M15/00 ,  A61M15/08 ,  A61K31/485 ,  A61K47/26 ,  A61K47/18 ,  A61P25/32 ,  A61K47/02

CPC分类号： A61K9/0043 ,  A61K9/08 ,  A61K31/485 ,  A61K45/06 ,  A61K47/02 ,  A61K47/183 ,  A61K47/186 ,  A61K47/26 ,  A61K47/36 ,  A61M11/006 ,  A61M15/0068 ,  A61M15/06 ,  A61M15/08 ,  A61P25/32 ,  A61K2300/00

摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising naltrexone are provided. Formulations and methods of treating alcohol use disorder and related conditions with the drug products are also provided.

公开(公告)号：US20210275444A1

公开(公告)日：2021-09-09

申请号：US17319221

申请日：2021-05-13

申请人： OPIANT PHARMACEUTICALS, INC.

发明人： Roger Crystal ,  Phil Skolnick

IPC分类号： A61K9/00 ,  A61K31/485 ,  A61K9/08 ,  A61K47/02 ,  A61P25/36

摘要： Methods, pharmaceutical formulations and devices for the preventative treatment of incidental opioid overdose comprising the intramuscular or subcutaneous administration using an auto-injection device of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.

公开(公告)号：US20190262263A1

公开(公告)日：2019-08-29

申请号：US16348031

申请日：2017-11-09

申请人： Opiant Pharmaceuticals, Inc. ,  Aegis Therapeutics, LLC

发明人： Roger Crystal ,  Edward T. Maggio

IPC分类号： A61K9/00 ,  A61P25/36 ,  A61K31/485 ,  A61K9/08 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26

摘要： Drug products adapted for nasal delivery comprising naltrexone, alone or in combination with excipients, are provided. Pre-primed devices for intranasal administration of the drug products are also provided. In addition, methods for treating and preventing a variety of opioid receptor-mediated diseases, disorders, addictions, symptoms, reward-based behaviors, and conditions with the drugs products are provided.