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公开(公告)号：US11471437B2
公开(公告)日：2022-10-18
申请号：US16904359
申请日：2020-06-17
发明人： Phil Skolnick
IPC分类号： A61K31/397 , A61K9/00
摘要： Disclosed herein are formulations and methods for reversing one or more symptoms of cannabinoid hyperemesis syndrome (CHS) or one or more symptoms thereof, comprising parenterally administering a CB1 antagonist in an amount sufficient to reverse the CHS or symptom(s).
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公开(公告)号：US20210220346A1
公开(公告)日：2021-07-22
申请号：US17055647
申请日：2019-05-15
发明人： Roger Crystal , Phil Skolnick , Edward T. Maggio
摘要： Formulations and methods for the preventative treatment of incidental opioid overdose comprising the intranasal (IN) administration of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.
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公开(公告)号：US20180169006A1
公开(公告)日：2018-06-21
申请号：US15660422
申请日：2017-07-26
IPC分类号： A61K9/00 , A61K47/18 , A61K9/12 , A61K31/485 , A61K45/06 , A61K47/02 , A61M15/00 , A61M15/08
CPC分类号： A61K9/0043 , A61K9/0019 , A61K9/12 , A61K31/485 , A61K45/06 , A61K47/02 , A61K47/183 , A61K47/186 , A61M15/009 , A61M15/08 , A61M2205/58 , A61M2205/581
摘要： Provided herein are drug products comprising a combination of an opioid receptor agonist and an opioid receptor agonists, including co-packaged drug products comprising an opioid receptor agonist and an opioid receptor antagonist in a delivery device selected from a hand-held auto-injector and a pre-primed nasal delivery device, and methods of prescribing and dispensing same. Methods of lowering opioid overdose risk by providing a combination of an opioid receptor agonist and an opioid receptor agonists, for example by co-packaging an opioid receptor agonist and an opioid receptor antagonist in a delivery device, are also provided.
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公开(公告)号：US11458091B2
公开(公告)日：2022-10-04
申请号：US16461354
申请日：2017-11-09
发明人： Roger Crystal , Edward T. Maggio
IPC分类号： A01N43/00 , A01N43/46 , A61K31/55 , A61K9/00 , A61P25/36 , A61K31/485 , A61K47/02 , A61K47/18 , A61K47/26
摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.
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5.发明申请公开(公告)号：US20210401827A1
公开(公告)日：2021-12-30
申请号：US17291979
申请日：2019-11-07
发明人： Roger Crystal , Phil Skolnick
IPC分类号： A61K31/485 , A61K9/00 , A61P25/36 , A61K9/08 , A61K47/02
摘要： Methods, pharmaceutical formulations and devices for the preventative treatment of incidental opioid overdose comprising the intramuscular or subcutaneous administration using an auto-injection device of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.
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公开(公告)号：US20210275519A1
公开(公告)日：2021-09-09
申请号：US17127649
申请日：2020-12-18
IPC分类号： A61K31/485 , A61K9/00 , A61M11/00 , A61K47/02 , A61K9/08 , A61M15/08 , A61M31/00 , A61K47/18
摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
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公开(公告)号：US20200060967A1
公开(公告)日：2020-02-27
申请号：US16461354
申请日：2017-11-09
发明人： Roger Crystal , Edward T. Maggio
摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.
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公开(公告)号：US20170304295A1
公开(公告)日：2017-10-26
申请号：US15494270
申请日：2017-04-21
CPC分类号： A61K31/485 , A61K9/0043 , A61K9/08 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/186 , A61M11/001 , A61M11/006 , A61M15/08 , A61M31/00
摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
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公开(公告)号：US09629965B2
公开(公告)日：2017-04-25
申请号：US15335145
申请日：2016-10-26
IPC分类号： A61M31/00 , A61M5/00 , A61F13/00 , A61K31/56 , A61M11/00 , A61K9/00 , A61K31/485 , A61K47/02 , A61K47/18 , A61K9/08 , A61M15/08
CPC分类号： A61K31/485 , A61K9/0043 , A61K9/08 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/186 , A61M11/001 , A61M11/006 , A61M15/08 , A61M31/00
摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
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公开(公告)号：US20170043107A1
公开(公告)日：2017-02-16
申请号：US15335145
申请日：2016-10-26
CPC分类号： A61K31/485 , A61K9/0043 , A61K9/08 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/186 , A61M11/001 , A61M11/006 , A61M15/08 , A61M31/00
摘要： Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
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