公开(公告)号：US20220088083A1

公开(公告)日：2022-03-24

申请号：US17423285

申请日：2020-01-17

Applicant: OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Yasushi KIKUCHI ,  Tomoki TAMAKOSHI

IPC: A61K35/28 ,  A61K38/39 ,  A61K9/00 ,  C07H21/02 ,  A61P17/00 ,  C12N15/90

Abstract: The present disclosure relates to a composition for use in the treatment of dystrophic epidermolysis bullosa, comprising a cell obtained from a patient with dystrophic epidermolysis bullosa, wherein the cell is a mesenchymal stem cell and genetically modified to produce type VII collagen. The present disclosure also relates to a composition for use in the treatment of dystrophic epidermolysis bullosa, comprising a cell that produces type VII collagen, wherein the composition is to be administered into a blister.

公开(公告)号：US20240050481A1

公开(公告)日：2024-02-15

申请号：US18017149

申请日：2021-07-21

Applicant: OSAKA UNIVERSITY ,  STEMRIM INC.

Inventor： Katsuto TAMAI ,  Yasushi KIKUCHI ,  Tomoki TAMAKOSHI ,  Takehiko YAMAZAKI

IPC: A61K35/28 ,  C12N5/0775 ,  C07K14/78 ,  A61P17/00

CPC classification number: A61K35/28 ,  C12N5/0668 ,  C07K14/78 ,  A61P17/00

Abstract: The present disclosure includes a composition for use in the treatment of dystrophic epidermolysis bullosa, comprising a blister-derived cell of a patient with dystrophic epidermolysis bullosa that is genetically modified to produce type VII collagen.