公开(公告)号：US20210386823A1

公开(公告)日：2021-12-16

申请号：US17287636

申请日：2019-10-25

Applicant: OSAKA UNIVERSITY ,  STEMRIM INC.

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Eiji SASAKI ,  Takahiro TSUSHIMA ,  Takehiko YAMAZAKI

IPC: A61K38/17 ,  A61P19/02

Abstract: The inventors of the present invention searched for a substance that is effective in treating a cartilage disorder, and as a result, found that, in an animal model of joint cartilage deficiency, an HMGB1 fragment peptide having a specific amino acid sequence exhibits the effect of reproducing a healthy cartilage tissue including a hyaline cartilage. Based on this finding, the present invention provides a pharmaceutical composition that contains the specific HMGB1 fragment peptide and that is for preventing and/or treating a cartilage disorder.

公开(公告)号：US20200291359A1

公开(公告)日：2020-09-17

申请号：US16768203

申请日：2018-11-30

Applicant: STEMRIM INC. ,  OSAKA UNIVERSITY

Inventor： Katsuto TAMAI ,  Takashi SHIMBO ,  Eiji SASAKI ,  Takehiko YAMAZAKI

IPC: C12N5/0775 ,  A61K35/28 ,  G01N33/50 ,  C07K14/47

Abstract: The inventors discovered that ectodermal mesenchymal stem cells circulating in peripheral blood that are induced by necrotic tissue damage contribute to the regeneration of damaged tissue. On the basis of this discovery, provided are ectodermal mesenchymal stem cells, a method for producing the same, and a screening method for a substance having pluripotent stem cell inductive activity, the screening method using cells induced by necrotic tissue damage in peripheral blood as an index.