公开(公告)号：US20170198031A1

公开(公告)日：2017-07-13

申请号：US15298527

申请日：2016-10-20

申请人： OncoMed Pharmaceuticals, Inc.

发明人： Austin L. GURNEY ,  Timothy Charles HOEY ,  Edward Thein Htun van der HORST ,  Aaron Ken SATO ,  Yuan Ching LIU ,  Maureen Fitch BRUHNS ,  John A. LEWICKI

IPC分类号： C07K16/22 ,  A61K45/06 ,  A61K31/337 ,  A61K39/395

CPC分类号： C07K16/22 ,  A61K31/337 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61N5/10 ,  C07H21/04 ,  C07K14/435 ,  C07K14/71 ,  C07K16/28 ,  C07K16/30 ,  C07K16/3046 ,  C07K16/462 ,  C07K16/464 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C12N5/0693 ,  C12N5/12 ,  C12N15/63 ,  C12N15/79 ,  C12N2501/998

摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.