公开(公告)号：US11814652B2

公开(公告)日：2023-11-14

申请号：US16981628

申请日：2019-03-20

申请人： Oriental Yeast Co., Ltd.

发明人： Hidenori Matsuo ,  Ayumi Ga ,  Munehiro Yamada ,  Yoshiya Tomimori

IPC分类号： C12N5/074

CPC分类号： C12N5/0696 ,  C12N2500/38

摘要： The object of the present invention is to provide a material for efficiently obtaining differentiated cells from pluripotent stem cells. That is, the present invention relates to a pluripotent stem cell differentiation-promoting agent containing, as an active ingredient, a β-nicotinamide mononucleotide or a pharmacologically acceptable salt thereof, and a solvate thereof, and a method for differentiating pluripotent stem cells, including culturing pluripotent stern cells in a culture medium containing a β-nicotinamide mononucleotide or a pharmacologically acceptable salt thereof, and a solvate thereof.

公开(公告)号：US11634690B2

公开(公告)日：2023-04-25

申请号：US16481760

申请日：2018-01-31

申请人： Oriental Yeast Co., Ltd.

发明人： Jun Nojima ,  Hidenori Matsuo ,  Yuriko Furuya ,  Hisataka Yasuda

IPC分类号： C12N5/074 ,  C12N5/0775

摘要： An object of the present invention is to provide a material capable of further accelerating growth of pluripotent stem cells, such as pluripotent stem cells, without impairing pluripotency thereof. In other words, the invention is an agent for accelerating growth of pluripotent stem cells, containing a β-nicotinamide mononucleotide or a pharmaceutically acceptable salt thereof, and a solvate thereof as an active ingredient; and is a method for culturing pluripotent stem cells, including culturing pluripotent stem cells in a culture medium that contains a β-nicotinamide mononucleotide or a pharmaceutically acceptable salt thereof, and a solvate thereof.