公开(公告)号：US09452135B2

公开(公告)日：2016-09-27

申请号：US14383163

申请日：2013-03-19

Applicant: PARTICLE DYNAMICS INTERNATIONAL, LLC

Inventor： Irwin Jacobs ,  Stephen Gee ,  Paul Brady

IPC: A61K9/107 ,  A61K31/137 ,  A61K31/167 ,  A61K31/197 ,  A61K31/455 ,  A61K35/60 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A61K9/00 ,  A61K9/06 ,  A61K9/14 ,  A61K9/70 ,  A61K31/192 ,  A61K45/06 ,  A23L1/30 ,  A23L1/05 ,  A23L1/052 ,  A23L1/0526 ,  A23L1/054

CPC classification number: A61K9/06 ,  A23L29/20 ,  A23L29/206 ,  A23L29/238 ,  A23L29/269 ,  A23L29/272 ,  A23L33/12 ,  A23V2002/00 ,  A61K9/0065 ,  A61K9/107 ,  A61K9/146 ,  A61K9/148 ,  A61K9/7007 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/197 ,  A61K31/202 ,  A61K31/455 ,  A61K35/60 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A23V2200/30 ,  A23V2200/31 ,  A23V2200/326 ,  A23V2250/186 ,  A23V2250/1882

Abstract: The present invention generally relates to dosage forms for oral administration including one or more gelling agents. In particular, the present invention is directed to gelling agent-based dosage forms that are easily administered and taken, or swallowed. The present invention is also directed to gelling agent-based dosage forms that exhibit relatively low syneresis, are thermally stable, exhibit substantially constant active ingredient concentration, and/or exhibit one or more advantageous rheological properties. In particular, the present invention is directed to such gels containing one or more omega-3 fatty acids. The gelling agent-based dosage forms of the present invention are suitable for administration of a relatively large dose of active ingredient. The gelling agent-based dosage forms of the present invention are also suitable for administration of multiple active ingredients. Dosage forms of the present invention also provide tamper resistance and, thus, prevent recovery or diversion of active ingredients contained therein. The gelling agent-based dosage forms are also suitable for use as gastro-retentive and sustained release dosage forms.

Abstract translation: 本发明一般涉及用于口服给药的剂型，包括一种或多种胶凝剂。 特别地，本发明涉及容易施用和服用或吞咽的基于胶凝剂的剂型。 本发明还涉及显示相对低的脱水收缩，热稳定，显示基本上恒定的活性成分浓度和/或表现出一个或多个有利的流变学性质的基于胶凝剂的剂型。 特别地，本发明涉及含有一种或多种ω-3脂肪酸的凝胶。 本发明的基于胶凝剂的剂型适用于施用较大剂量的活性成分。 本发明的基于胶凝剂的剂型也适用于多种活性成分的施用。 本发明的剂型还提供抗篡改性，并因此防止其中含有的活性成分的回收或转移。 基于胶凝剂的剂型也适合用作保持性和持续释放剂型。

公开(公告)号：US20150140113A1

公开(公告)日：2015-05-21

申请号：US14383163

申请日：2013-03-19

Applicant: PARTICLE DYNAMICS INTERNATIONAL, LLC

Inventor： Irwin Jacobs ,  Stephen Gee ,  Paul Brady

IPC: A61K9/107 ,  A61K9/00 ,  A61K47/36 ,  A61K47/14 ,  A61K47/46 ,  A61K31/197 ,  A61K47/26 ,  A61K47/02 ,  A61K31/167 ,  A61K35/60 ,  A61K31/137 ,  A61K31/455 ,  A61K47/12

CPC classification number: A61K9/06 ,  A23L29/20 ,  A23L29/206 ,  A23L29/238 ,  A23L29/269 ,  A23L29/272 ,  A23L33/12 ,  A23V2002/00 ,  A61K9/0065 ,  A61K9/107 ,  A61K9/146 ,  A61K9/148 ,  A61K9/7007 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/197 ,  A61K31/202 ,  A61K31/455 ,  A61K35/60 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A23V2200/30 ,  A23V2200/31 ,  A23V2200/326 ,  A23V2250/186 ,  A23V2250/1882

Abstract: The present invention generally relates to dosage forms for oral administration including one or more gelling agents. In particular, the present invention is directed to gelling agent-based dosage forms that are easily administered and taken, or swallowed. The present invention is also directed to gelling agent-based dosage forms that exhibit relatively low syneresis, are thermally stable, exhibit substantially constant active ingredient concentration, and/or exhibit one or more advantageous rheological properties. In particular, the present invention is directed to such gels containing one or more omega-3 fatty acids. The gelling agent-based dosage forms of the present invention are suitable for administration of a relatively large dose of active ingredient. The gelling agent-based dosage forms of the present invention are also suitable for administration of multiple active ingredients. Dosage forms of the present invention also provide tamper resistance and, thus, prevent recovery or diversion of active ingredients contained therein. The gelling agent-based dosage forms are also suitable for use as gastro-retentive and sustained release dosage forms.

Abstract translation: 本发明一般涉及用于口服给药的剂型，包括一种或多种胶凝剂。 特别地，本发明涉及容易施用和服用或吞咽的基于胶凝剂的剂型。 本发明还涉及显示相对低的脱水收缩，热稳定，显示基本上恒定的活性成分浓度和/或表现出一个或多个有利的流变学性质的基于胶凝剂的剂型。 特别地，本发明涉及含有一种或多种ω-3脂肪酸的凝胶。 本发明的基于胶凝剂的剂型适用于施用较大剂量的活性成分。 本发明的基于胶凝剂的剂型也适用于多种活性成分的施用。 本发明的剂型还提供抗篡改性，并因此防止其中含有的活性成分的回收或转移。 基于胶凝剂的剂型也适合用作保持性和持续释放剂型。

公开(公告)号：US20160374942A1

公开(公告)日：2016-12-29

申请号：US15238070

申请日：2016-08-16

Applicant: PARTICLE DYNAMICS INTERNATIONAL, LLC

Inventor： Irwin Jacobs ,  Stephen Gee ,  Paul Brady

IPC: A61K9/06 ,  A61K47/46 ,  A61K31/202 ,  A61K9/00 ,  A61K31/167 ,  A61K31/137 ,  A61K47/36 ,  A61K31/455

CPC classification number: A61K9/06 ,  A23L29/20 ,  A23L29/206 ,  A23L29/238 ,  A23L29/269 ,  A23L29/272 ,  A23L33/12 ,  A23V2002/00 ,  A61K9/0065 ,  A61K9/107 ,  A61K9/146 ,  A61K9/148 ,  A61K9/7007 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/197 ,  A61K31/202 ,  A61K31/455 ,  A61K35/60 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A23V2200/30 ,  A23V2200/31 ,  A23V2200/326 ,  A23V2250/186 ,  A23V2250/1882

Abstract: The present invention generally relates to dosage forms for oral administration including one or more gelling agents. In particular, the present invention is directed to gelling agent-based dosage forms that are easily administered and taken, or swallowed. The present invention is also directed to gelling agent-based dosage forms that exhibit relatively low syneresis, are thermally stable, exhibit substantially constant active ingredient concentration, and/or exhibit one or more advantageous rheological properties. In particular, the present invention is directed to such gels containing one or more omega-3 fatty acids. The gelling agent-based dosage forms of the present invention are suitable for administration of a relatively large dose of active ingredient. The gelling agent-based dosage forms of the present invention are also suitable for administration of multiple active ingredients. Dosage forms of the present invention also provide tamper resistance and, thus, prevent recovery or diversion of active ingredients contained therein. The gelling agent-based dosage forms are also suitable for use as gastro-retentive and sustained release dosage forms.