公开(公告)号：US09452135B2

公开(公告)日：2016-09-27

申请号：US14383163

申请日：2013-03-19

Applicant: PARTICLE DYNAMICS INTERNATIONAL, LLC

Inventor： Irwin Jacobs ,  Stephen Gee ,  Paul Brady

IPC: A61K9/107 ,  A61K31/137 ,  A61K31/167 ,  A61K31/197 ,  A61K31/455 ,  A61K35/60 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A61K9/00 ,  A61K9/06 ,  A61K9/14 ,  A61K9/70 ,  A61K31/192 ,  A61K45/06 ,  A23L1/30 ,  A23L1/05 ,  A23L1/052 ,  A23L1/0526 ,  A23L1/054

CPC classification number: A61K9/06 ,  A23L29/20 ,  A23L29/206 ,  A23L29/238 ,  A23L29/269 ,  A23L29/272 ,  A23L33/12 ,  A23V2002/00 ,  A61K9/0065 ,  A61K9/107 ,  A61K9/146 ,  A61K9/148 ,  A61K9/7007 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/197 ,  A61K31/202 ,  A61K31/455 ,  A61K35/60 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A23V2200/30 ,  A23V2200/31 ,  A23V2200/326 ,  A23V2250/186 ,  A23V2250/1882

Abstract: The present invention generally relates to dosage forms for oral administration including one or more gelling agents. In particular, the present invention is directed to gelling agent-based dosage forms that are easily administered and taken, or swallowed. The present invention is also directed to gelling agent-based dosage forms that exhibit relatively low syneresis, are thermally stable, exhibit substantially constant active ingredient concentration, and/or exhibit one or more advantageous rheological properties. In particular, the present invention is directed to such gels containing one or more omega-3 fatty acids. The gelling agent-based dosage forms of the present invention are suitable for administration of a relatively large dose of active ingredient. The gelling agent-based dosage forms of the present invention are also suitable for administration of multiple active ingredients. Dosage forms of the present invention also provide tamper resistance and, thus, prevent recovery or diversion of active ingredients contained therein. The gelling agent-based dosage forms are also suitable for use as gastro-retentive and sustained release dosage forms.

Abstract translation: 本发明一般涉及用于口服给药的剂型，包括一种或多种胶凝剂。 特别地，本发明涉及容易施用和服用或吞咽的基于胶凝剂的剂型。 本发明还涉及显示相对低的脱水收缩，热稳定，显示基本上恒定的活性成分浓度和/或表现出一个或多个有利的流变学性质的基于胶凝剂的剂型。 特别地，本发明涉及含有一种或多种ω-3脂肪酸的凝胶。 本发明的基于胶凝剂的剂型适用于施用较大剂量的活性成分。 本发明的基于胶凝剂的剂型也适用于多种活性成分的施用。 本发明的剂型还提供抗篡改性，并因此防止其中含有的活性成分的回收或转移。 基于胶凝剂的剂型也适合用作保持性和持续释放剂型。

公开(公告)号：US20160165933A1

公开(公告)日：2016-06-16

申请号：US14878657

申请日：2015-10-08

Applicant: SIS (Science in Sport) Limited

Inventor： Timothy John Lawson ,  Alan Whitfield ,  Simon James Lawson

IPC: A23L1/05 ,  A61K31/522

CPC classification number: A23L29/27 ,  A23L2/52 ,  A23L29/20 ,  A23L29/212 ,  A23L29/272 ,  A23L33/00 ,  A23L33/40 ,  A23V2002/00

Abstract: There is provided a method of manufacturing a nutritional composition comprising carbohydrate in an amount or at least 250 g l−1 of composition. The method comprises the steps of: (i) combining a first gelling agent and water; (ii) heating the mixture produced in step (i) to a temperature of between 60° C. and 100° C.; (iii) combining a second gelling agent with the heated mixture of step (ii) with mixing and (iv) maintaining the mixture produce in step (iii) at a temperature of between 70° C. and 100° C. for between 10 and 120 minutes; with a carbohydrate component being combined with the mixture during one or more of said steps. Also provided is a nutritional composition.

Abstract translation: 提供了一种制造营养组合物的方法，该营养组合物包含组合物的量或至少250克/升的碳水化合物。 该方法包括以下步骤：（i）将第一胶凝剂与水混合; （ii）将步骤（i）中制备的混合物加热至60℃至100℃的温度; （iii）将第二胶凝剂与步骤（ii）的加热混合物混合并混合，和（iv）将步骤（iii）中的混合物在70℃和100℃之间的温度下保持在10和 120分钟; 在一个或多个所述步骤期间将碳水化合物组分与所述混合物混合。 还提供营养组合物。

公开(公告)号：US20160095341A1

公开(公告)日：2016-04-07

申请号：US14966848

申请日：2015-12-11

Applicant: The Hershey Company

Inventor： Stephen J. CROZIER ,  David A. STUART

IPC: A23L1/30 ,  A23L1/05 ,  A23L1/0522 ,  A23L2/38

CPC classification number: A23G1/48 ,  A23G1/325 ,  A23L2/52 ,  A23L33/105

Abstract: The invention includes compositions and methods for improving exercise performance or improving recovery of muscle tissue after exercise performance. One method includes administering a composition of a plant-derived nitrate and a cocoa-derived product daily and before exercise. The synergistic combination of nitrate and cocoa polyphenols acts to improve recovery from a strenuous exercise bout.

公开(公告)号：US09278989B2

公开(公告)日：2016-03-08

申请号：US14383654

申请日：2013-03-08

Applicant: KYUSHU UNIVERSITY ,  INSTITUTE OF SYSTEMS, INFORMATION TECHNOLOGIES AND NANOTECHNOLOGIES ,  NISSAN CHEMICAL INDUSTRIES, LTD.

Inventor： Fumiyasu Ono ,  Seiji Shinkai ,  Osamu Hirata

IPC: C07H15/04 ,  A23L1/05 ,  A61K8/60 ,  C07H9/04 ,  A61Q19/00 ,  A61K8/04 ,  A61K47/26 ,  H01B1/12 ,  H01M10/052 ,  H01M10/0565 ,  C09K3/00

CPC classification number: C07H15/04 ,  A23L29/20 ,  A23V2002/00 ,  A61K8/042 ,  A61K8/60 ,  A61K47/26 ,  A61K2800/10 ,  A61K2800/48 ,  A61Q19/00 ,  C07H9/04 ,  C09K3/00 ,  H01B1/12 ,  H01M10/052 ,  H01M10/0565 ,  H01M2300/0085

Abstract: There is provided a novel gelator containing a sugar derivative. A gelator including a compound of Formula (1) or Formula (2): wherein each of R1 and R3 is independently a linear or branched alkyl group having a carbon atom number of 1 to 20, a cyclic C3-20 alkyl group, or a linear or branched alkenyl group having a carbon atom number of 2 to 20, n is 0 or an integer of 1 to 4, R2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R4 and R5 are each a hydroxy group.

Abstract translation: 提供了含有糖衍生物的新型凝胶剂。 包括式（1）或式（2）的化合物的凝胶剂：其中R 1和R 3各自独立地为碳原子数为1至20的直链或支链烷基，环状C 3-20烷基或 碳原子数为2〜20的直链或支链烯基，n为0或1〜4的整数，R2为氢原子，碳原子数为1〜10的直链或支链烷基，或 任选具有取代基的芳基，R4和R5各自为羟基。

公开(公告)号：US20150327566A1

公开(公告)日：2015-11-19

申请号：US14653834

申请日：2012-12-27

Applicant: Jean-Claude EPIPHANI ,  AR21

Inventor： Jean-Claude Epiphani

IPC: A23D7/04 ,  A61K9/107 ,  A23L1/05 ,  A61K8/36 ,  A61K47/26 ,  A61K31/20 ,  A61K8/06 ,  A61K8/60

CPC classification number: A23D7/04 ,  A23L29/20 ,  A23V2002/00 ,  A61K8/062 ,  A61K8/361 ,  A61K8/602 ,  A61K8/922 ,  A61K9/107 ,  A61K31/20 ,  A61K47/26 ,  A61K2800/10 ,  A61K2800/21 ,  A61K2800/81 ,  A61Q19/00

Abstract: The invention relates to a method which includes the following steps: mixing hydrophilic components, including water and an emulsifying saponin which is less than 1% of the emulsion regardless of the proportion of the oily phase; mixing lipophilic components, including the oily active substance, which can reach 40% of the emulsion; a first homogenization of the two preceding phases using a rotor/stator or ultrasonic mixer until a mean diameter of less than 6 μm of the oily droplets is obtained; and a second homogenization of the preceding mixture using a high-pressure homogenizer until a mean diameter of less than 0.4 μm of the oily droplets is obtained.

Abstract translation: 本发明涉及一种包括以下步骤的方法：将亲水性成分（包括水和乳化皂苷）混合在一起，该乳化皂苷小于油相的比例小于乳液的1％ 混合亲油性组分，包括油性活性物质，其可以达到乳液的40％; 使用转子/定子或超声波混合器进行前两相的第一均化，直到得到小于6μm的油滴的平均直径; 并使用高压均化器对前述混合物进行第二次均化，直到获得小于0.4μm的油滴的平均直径。

公开(公告)号：US09131713B2

公开(公告)日：2015-09-15

申请号：US13014951

申请日：2011-01-27

Applicant: Eberhard Dick ,  Simone Walter

Inventor： Eberhard Dick ,  Simone Walter

IPC: A23L1/308 ,  A23L1/05 ,  B32B3/00 ,  A61K9/14 ,  A61K8/65 ,  A23J1/00 ,  B02C19/00 ,  A23J3/04 ,  A23L1/305 ,  A23L1/0562 ,  A23C9/137 ,  A23C19/082 ,  A23G3/34 ,  A23J3/00 ,  A23L1/24 ,  A23L1/307 ,  A61K38/39

CPC classification number: A23L1/05625 ,  A23C9/137 ,  A23C19/082 ,  A23G3/346 ,  A23J3/04 ,  A23L27/60 ,  A23L29/284 ,  A23L33/17 ,  A23L33/20 ,  A23L33/28 ,  A23V2002/00 ,  A61K38/39 ,  Y10T428/2982 ,  A23G2200/10 ,  A23V2200/124 ,  A23V2250/5422 ,  A23V2250/628 ,  A23V2250/61 ,  A23V2250/606

Abstract: In order to provide a product that is suitable as fat substitute in foods, which can be produced simply and inexpensively and is deemed safe from the nutritional physiology viewpoint and with which the typical texture of fat-containing foods can be simulated as favorably as possible, particles of collagen material are proposed which are substantially insoluble and swellable in water, wherein in swollen state the particles have an average diameter of less than approximately 150 μm. A process for the production of this product is additionally proposed.

Abstract translation: 为了提供适合作为食品中的脂肪替代物的产品，其可以简单廉价地制造，并且从营养生理观点来看被认为是安全的，并且可以有利地模拟含脂肪食品的典型纹理， 提出了在水中基本上不溶和溶胀的胶原材料颗粒，其中在溶胀状态下，颗粒的平均直径小于约150μm。 另外提出了生产该产品的方法。

公开(公告)号：US09084741B2

公开(公告)日：2015-07-21

申请号：US12682747

申请日：2007-10-12

Applicant: Atsuko Fukui

Inventor： Atsuko Fukui

IPC: A61K9/16 ,  A23L1/05 ,  A61K36/00 ,  A23L1/00 ,  A23L1/22 ,  A23L2/38 ,  A23L2/52 ,  A61K9/00

CPC classification number: A61K36/00 ,  A23L2/38 ,  A23L2/52 ,  A23L27/86 ,  A23P10/20 ,  A23V2002/00 ,  A61K9/0095 ,  A23V2200/16 ,  A23V2250/64 ,  A23V2250/194

Abstract: Provided is a granular jelly beverage for medication used for taking the crude drug(s) and/or herbal medicine(s), which granular jelly beverage for medication comprises (a) 0.1 to 15.0% by mass of a bitterness masking ingredient comprising a plant fat and oil and/or animal fat and oil; (b) 5.0 to 20.0% by mass of a bitterness masking auxiliary ingredient comprising a sugar alcohol; (c) 0.1 to 5.0% by mass of an aggregation-inhibiting gelling ingredient; (d) 0.1 to 5.0% by mass of at least one taste adjusting ingredient selected from the group consisting of acids, derivatives thereof and salts thereof; and (e) a balance of water.

Abstract translation: 本发明提供一种用于服用生药和/或草药的药物用颗粒状果冻饮料，该药用颗粒状果冻饮料包含（a）0.1〜15.0质量％的含有植物的苦味掩蔽成分 油脂和/或动物油脂; （b）5.0〜20.0质量％的含有糖醇的苦味掩蔽辅助成分; （c）0.1〜5.0质量％的聚集抑制胶凝成分; （d）0.1〜5.0质量％的至少一种选自酸，其衍生物和其盐的调味成分; 和（e）水的平衡。

公开(公告)号：US08911770B2

公开(公告)日：2014-12-16

申请号：US12818692

申请日：2010-06-18

Applicant: Alessandra Grassi

Inventor： Alessandra Grassi

IPC: A61K9/70 ,  A61K9/00 ,  A61K31/525 ,  A61K33/30 ,  A61K33/32 ,  A23L1/00 ,  A23L1/05 ,  A61K31/4985 ,  A61K31/045 ,  A23L1/30 ,  A61K31/375 ,  A61K31/714 ,  A61K31/4188 ,  A61K31/14 ,  A61K33/34 ,  A61K31/355 ,  A61K31/197 ,  A61K31/455 ,  A61K31/44 ,  A61K33/22 ,  A61K33/06 ,  A61K31/685 ,  A61K33/24 ,  A61K33/18 ,  A61K31/07 ,  A61K31/34 ,  A61K31/015 ,  A61K31/195 ,  A23L1/304 ,  A61K31/51 ,  A61K33/26 ,  A61K31/593 ,  A61K31/4415 ,  A61K45/06 ,  A23L1/302

CPC classification number: A61K9/0056 ,  A23L29/20 ,  A23L33/105 ,  A23L33/115 ,  A23L33/15 ,  A23L33/16 ,  A23P20/20 ,  A23V2002/00 ,  A61K9/7007 ,  A61K31/015 ,  A61K31/045 ,  A61K31/07 ,  A61K31/14 ,  A61K31/195 ,  A61K31/197 ,  A61K31/34 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/44 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/4985 ,  A61K31/51 ,  A61K31/525 ,  A61K31/593 ,  A61K31/675 ,  A61K31/685 ,  A61K31/714 ,  A61K33/06 ,  A61K33/18 ,  A61K33/22 ,  A61K33/24 ,  A61K33/26 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/334 ,  A23V2250/7042 ,  A23V2250/7044 ,  A23V2250/7046 ,  A23V2250/705 ,  A23V2250/7052 ,  A23V2250/706 ,  A23V2250/708 ,  A23V2250/72

Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.

Abstract translation: 提供既可食用又可溶解的条状物，其包含至少一种营养不良膳食补充剂的参考每日摄入量（RDI）的至少2％的剂量，或用于预防/治疗酒精诱导的宿醉。 一种使用可溶性口服给药条治疗营养不良和/或预防和治疗酒精诱导宿醉的方法。

公开(公告)号：US08865241B1

公开(公告)日：2014-10-21

申请号：US12893322

申请日：2010-09-29

Applicant: Stan Bower ,  Ellen Burke ,  Nancy E. Harding ,  Yamini N. Patel ,  J. Carrie Schneider ,  Dagmar Meissner ,  Neil A. Morrison ,  Ralph Bezanson

Inventor： Stan Bower ,  Ellen Burke ,  Nancy E. Harding ,  Yamini N. Patel ,  J. Carrie Schneider ,  Dagmar Meissner ,  Neil A. Morrison ,  Ralph Bezanson

IPC: A23L1/05 ,  C07H17/00 ,  C08B37/00 ,  C07H1/06 ,  C07H1/08

CPC classification number: C08B37/006 ,  A23L21/10 ,  A23L21/15 ,  A23L29/269 ,  C12N1/20 ,  C12P7/62 ,  C12P19/04

Abstract: The invention relates to mutant strains of the genus Sphingomonas which have a mutation in at least one gene encoding a protein involved in polyhydroxybutyrate (“PHB”) synthesis that allows the mutant strains to produce PHB-deficient Sphingans. The invention is also directed to a process for preparing a clarified Sphingan solution comprising heating aqueous Sphingan solution, in particular PHB-deficient Sphingan solution, to a clarification temperature of about 30° C. to about 70° C., and treating the solution with a clarification agent and enzymes. In addition, the invention is directed to a food or industrial product comprising a PHB-deficient and/or clarified Sphingan. One particular embodiment of the invention is directed to a clarified, PHB-deficient high-acyl gellan and the processes of making thereof.

Abstract translation: 本发明涉及鞘氨醇单胞菌属的突变菌株，其在编码参与多羟基丁酸酯（“PHB”）合成的蛋白质的至少一个基因中具有突变，其允许突变菌株产生PHB缺乏的鞘氨醇。 本发明还涉及一种制备澄清的鞘氨醇溶液的方法，其包括将鞘氨醇水溶液，特别是PHB缺乏的鞘氨醇溶液加热至约30℃至约70℃的澄清温度，并用 澄清剂和酶。 此外，本发明涉及包含PHB缺乏和/或澄清的鞘氨醇的食品或工业产品。 本发明的一个具体实施方案涉及澄清的PHB缺陷型高酰基结冷胶及其制备方法。

公开(公告)号：US08846126B2

公开(公告)日：2014-09-30

申请号：US13376864

申请日：2011-05-13

Applicant: Shireen S. Baseeth ,  Bruce R. Sebree

Inventor： Shireen S. Baseeth ,  Bruce R. Sebree

IPC: A23D9/00 ,  A23L1/05 ,  A21D2/16 ,  A21D13/00 ,  A23K1/16 ,  A23D7/01 ,  A23G3/34 ,  A23J7/00 ,  A23L1/00 ,  A23L1/035 ,  A21D2/32

CPC classification number: A21D13/16 ,  A21D2/16 ,  A21D2/165 ,  A21D2/32 ,  A23D7/011 ,  A23D7/013 ,  A23D9/013 ,  A23G3/346 ,  A23J7/00 ,  A23K20/158 ,  A23L29/10 ,  A23P20/11 ,  A23V2002/00 ,  A23G2200/08 ,  A23V2200/228 ,  A23V2250/1842 ,  A23V2250/192 ,  A23V2250/194 ,  A23V2250/5086

Abstract: The present invention is directed towards organogel compositions. Processes for producing such organogel compositions are further disclosed. The present invention is also directed towards uses of the novel organogel compositions in foods, beverages, nutraceuticals pharmaceuticals, pet food, or animal feed.

Abstract translation: 本发明涉及有机凝胶组合物。 进一步公开了生产这种有机凝胶组合物的方法。 本发明还涉及新型有机凝胶组合物在食品，饮料，营养药品，宠物食品或动物饲料中的用途。