公开(公告)号：US11712480B2

公开(公告)日：2023-08-01

申请号：US16321695

申请日：2017-07-31

Applicant: PFIZER INC.

Inventor： Russell George Dushin ,  Daniel P. Uccello ,  Jeremy Starr ,  Ye Che ,  Mark Flanagan ,  Jeffrey M. Casavant ,  Christopher John O'Donnell ,  Gary Frederick Filzen ,  Jennifer Young ,  Joseph A. Abramite ,  Lawrence N. Tumey ,  Ludivine Moine ,  Adam Matthew Gilbert ,  Lee R. Roberts

IPC: A61K47/54 ,  A61K47/68 ,  C07K4/00 ,  C07K5/02 ,  C07K7/02 ,  A61K47/50 ,  C07K5/062

CPC classification number: A61K47/6855 ,  A61K47/50 ,  A61K47/545 ,  A61K47/6867 ,  C07K4/00 ,  C07K5/0205 ,  C07K5/06052 ,  C07K7/02

Abstract: The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula:




(wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drug conjugates, and the resulting antibody drug conjugates made with components having heteroaryl sulfone-based conjugation handles.

公开(公告)号：US20150148326A1

公开(公告)日：2015-05-28

申请号：US14608826

申请日：2015-01-29

Applicant: Pfizer Inc.

Inventor： Matthew F. Brown ,  Mark J. Mitton-Fry ,  Seungil Han ,  Manjinder Lall ,  Mark Plummer ,  Hud Lawrence Risley ,  Veerabahu Shanmugasundaram ,  Jeremy Starr

IPC: C07D417/14

CPC classification number: C07D417/14 ,  C07D205/08

Abstract: The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.

Abstract translation: 本发明涉及一类新颖的单链内酰胺衍生物及其用于治疗细菌感染的用途。

公开(公告)号：US20130252935A1

公开(公告)日：2013-09-26

申请号：US13778670

申请日：2013-02-27

Applicant: PFIZER INC.

Inventor： Matthew F. Brown ,  Mark J. Mitton-Fry ,  Seungil Han ,  Manjinder Lall ,  Mark Plummer ,  Hud Lawrence Risley ,  Veerabahu Shanmugasundaram ,  Jeremy Starr

IPC: C07D205/08

CPC classification number: C07D417/14 ,  C07D205/08

Abstract: The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.