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    Phase Separation Behavior Modifying Agents for Aqueous Two-Phase Separation Within Porous Material
    2.
    发明公开
    Phase Separation Behavior Modifying Agents for Aqueous Two-Phase Separation Within Porous Material 审中-公开

    公开(公告)号：US20230211257A1

    公开(公告)日：2023-07-06

    申请号：US18182372

    申请日：2023-03-13

    Applicant: PHASE DIAGNOSTICS, INC.

    Inventor： Yin To Chiu ,  Brian Sangwoo Lee ,  Garrett Lee Mosley ,  Beatrice S. Lim

    IPC: G01N1/40

    CPC classification number: G01N1/405 ,  G01N2001/4061

    Abstract: The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embodiment, the present method and device comprise ATPS components within a porous material and one or more phase separation behavior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components.

    Method and device of using aqueous two-phase systems (ATPS) for enhancing diagnostics for sexually transmitted infections
    3.
    发明授权
    Method and device of using aqueous two-phase systems (ATPS) for enhancing diagnostics for sexually transmitted infections 有权

    公开(公告)号：US11609232B2

    公开(公告)日：2023-03-21

    申请号：US16642910

    申请日：2018-08-30

    Applicant: PHASE DIAGNOSTICS, INC.

    Inventor： Yin To Chiu ,  Garrett Lee Mosley ,  Brian Sangwoo Lee

    IPC: C12Q1/00 ,  G01N33/571 ,  G01N1/34 ,  G01N1/40 ,  G01N33/543

    Abstract: This invention relates to a method and device for improving the accuracy and performance of detecting or diagnosing sexually transmitted infections (STIs) or STI-causing pathogens. In one embodiment, the present method and device are related to removing one or more interfering molecules such as urea from urine sample, where these interfering molecules alter the performance of Lateral-Flow Immunoassay (LFA). In one embodiment, an aqueous two-phase system (ATPS) embedded entirely within a porous material allows spontaneous phase separation and the target STI-causing pathogens is concentrated in one of the separated phases. In one embodiment, a detection module such as the Lateral-Flow Immunoassay (LFA) is used in connection with other modules so as to detect or diagnose the sexually transmitted infections or the pathogens associated with STIs with an improved performance.

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