公开(公告)号：US20150150995A1

公开(公告)日：2015-06-04

申请号：US14418907

申请日：2013-08-09

Applicant: PONO CORPORATION

Inventor： Karl Milton Taft, III ,  Jarred Roy Engelking

IPC: A61K47/48 ,  A61K31/546 ,  A61K33/38

CPC classification number: A61K47/48015 ,  A61K31/546 ,  A61K33/38 ,  A61K47/52 ,  A61K47/552 ,  C07D201/14 ,  C07D227/087 ,  C07D501/38 ,  C07H3/02 ,  C07H3/04 ,  C07H13/04

Abstract: Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.

Abstract translation: 本文公开了用于产生缀合的抗微生物化合物和缀合的抗癌化合物的合成方法。 与这些化合物在治疗感染中的用途有关的几个实施方案，特别是由耐药菌引起的那些。 一些实施方案涉及基于肿瘤细胞的代谢特征来靶向癌症。

公开(公告)号：US20150336915A1

公开(公告)日：2015-11-26

申请号：US14410474

申请日：2013-07-01

Applicant: Pono Corporation

Inventor： Jarred Roy Engelking ,  Karl Milton Taft

IPC: C07D281/00 ,  C07D245/02 ,  C07D225/02 ,  C07D255/02

CPC classification number: C07D225/02 ,  C07D245/02 ,  C07D255/02 ,  C07D281/00

Abstract: Disclosed herein are novel structures of proteasome inhibitors and methods for synthesizing and use thereof, including novel structures of proteasome inhibitors, such as syrbactins and its analogs, and methods for synthesizing them and using them for effective proteasome inhibition.

Abstract translation: 本文公开了蛋白酶体抑制剂的新结构及其合成和使用的方法，包括蛋白酶体抑制剂的新型结构如syrbactins及其类似物，以及用于合成它们并用于有效的蛋白酶体抑制的方法。