公开(公告)号：US20200247831A1

公开(公告)日：2020-08-06

申请号：US16642439

申请日：2018-08-31

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Kyo Han AHN ,  Hye Gun RYU ,  Kyeong Hwan KIM ,  Yong Woong JUN ,  Subhankar SINGHA

IPC: C07F7/08 ,  A61K49/00

Abstract: The present invention relates to a silicon-substituted amino-pyronin compound derivative, a cell- or tissue-imaging method using the same, a cancer diagnosis method using the same, and a method for preparation of the same. More specifically, serving as a two-photon absorption fluorescent substance which has longer absorption and emission wavelengths in red or near-infrared regions of 625 nm or greater, compared to conventional one-photon absorption fluorescent substances, the silicon-substituted amino-pyronin compound derivative can minimize the influence of self-fluorescence in a bioimaging study and is thus expected to be suitable for high-resolution imaging in deep tissues. A fluorescent probe developed on the basis of the fluorescent substance platform is expected to find an expanded range of applications in analyzing and imaging specific materials in vivo.