公开(公告)号：US20200247831A1

公开(公告)日：2020-08-06

申请号：US16642439

申请日：2018-08-31

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Kyo Han AHN ,  Hye Gun RYU ,  Kyeong Hwan KIM ,  Yong Woong JUN ,  Subhankar SINGHA

IPC: C07F7/08 ,  A61K49/00

Abstract: The present invention relates to a silicon-substituted amino-pyronin compound derivative, a cell- or tissue-imaging method using the same, a cancer diagnosis method using the same, and a method for preparation of the same. More specifically, serving as a two-photon absorption fluorescent substance which has longer absorption and emission wavelengths in red or near-infrared regions of 625 nm or greater, compared to conventional one-photon absorption fluorescent substances, the silicon-substituted amino-pyronin compound derivative can minimize the influence of self-fluorescence in a bioimaging study and is thus expected to be suitable for high-resolution imaging in deep tissues. A fluorescent probe developed on the basis of the fluorescent substance platform is expected to find an expanded range of applications in analyzing and imaging specific materials in vivo.

公开(公告)号：US20160202263A1

公开(公告)日：2016-07-14

申请号：US14745973

申请日：2015-06-22

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Kyo Han AHN ,  Hyunsoo MOON ,  Dokyoung KIM ,  Ki Hean KIM ,  Hye Gun RYU

IPC: G01N33/58 ,  G01N21/64 ,  C07D311/92 ,  G01N33/68 ,  C07D311/78 ,  C07D311/94

CPC classification number: G01N33/582 ,  A61K49/0021 ,  C07D311/78 ,  C07D311/92 ,  C07D311/94 ,  G01N21/6428 ,  G01N33/6896 ,  G01N2021/6439 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: Provided are acedan derivatives having an extended π bond, a method for preparing the acedan derivatives, and a method for two-photon microscopy imaging of amyloid-beta plaque using the acedan derivatives; more particularly, to two-photon absorbing fluorescent compounds having a longer absorption wavelength and emission wavelength than acedan and acedan derivatives which are conventional two-photon absorbing fluorophores. The compounds provided may be usefully used for in vivo imaging studies by imaging cells or tissue using the compounds, and may also be usefully used for diagnosing Alzheimer's disease by imaging amyloid-beta plaque using the compounds.

Abstract translation: 提供的是具有延伸＆ 键，一种制备acedan衍生物的方法，以及使用acedan衍生物的淀粉样蛋白-β斑块双光子显微镜成像方法。 更具体地说，涉及具有比作为常规双光子吸收荧光团的常规阿敏和acedan衍生物更长的吸收波长和发射波长的双光子吸收荧光化合物。 所提供的化合物可以有用地用于通过使用化合物成像细胞或组织的体内成像研究，并且还可以有用地用于通过使用该化合物成像淀粉样蛋白-β斑块来诊断阿尔茨海默氏病。