公开(公告)号：US20200247831A1

公开(公告)日：2020-08-06

申请号：US16642439

申请日：2018-08-31

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Kyo Han AHN ,  Hye Gun RYU ,  Kyeong Hwan KIM ,  Yong Woong JUN ,  Subhankar SINGHA

IPC: C07F7/08 ,  A61K49/00

Abstract: The present invention relates to a silicon-substituted amino-pyronin compound derivative, a cell- or tissue-imaging method using the same, a cancer diagnosis method using the same, and a method for preparation of the same. More specifically, serving as a two-photon absorption fluorescent substance which has longer absorption and emission wavelengths in red or near-infrared regions of 625 nm or greater, compared to conventional one-photon absorption fluorescent substances, the silicon-substituted amino-pyronin compound derivative can minimize the influence of self-fluorescence in a bioimaging study and is thus expected to be suitable for high-resolution imaging in deep tissues. A fluorescent probe developed on the basis of the fluorescent substance platform is expected to find an expanded range of applications in analyzing and imaging specific materials in vivo.

公开(公告)号：US20170327509A1

公开(公告)日：2017-11-16

申请号：US15512624

申请日：2015-05-06

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Kyo Han AHN ,  Hyunsoo MOON ,  Dokyoung KIM ,  Subhankar SINGHA ,  Basab ROY ,  Sunderraman SAMBASIVAN

IPC: C07D487/08 ,  C07D221/14 ,  C07D207/08 ,  C07C231/08 ,  C07C221/00 ,  A61K49/00 ,  C07D295/116 ,  C07C303/38 ,  C07C2601/14

CPC classification number: C07D487/08 ,  A61K49/0021 ,  C07C221/00 ,  C07C225/22 ,  C07C231/08 ,  C07C233/33 ,  C07C303/38 ,  C07C311/20 ,  C07C2601/14 ,  C07D207/08 ,  C07D221/14 ,  C07D295/116

Abstract: The present invention relates to new one-photon or two-photon absorbing fluorophores, a method for preparing the same, and a method for cellular imaging using the same, and more particularly, to new two-photon absorbing fluorophores having higher fluorescence quantum yield and two-photon absorption cross-section value than those of the conventional two-photon absorbing fluorophore, acedan, and thus are promisingly applicable in bioimaging. The design strategy and the compounds according to the present invention may practically utilized for developing new D-π-A fluorophores.