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公开(公告)号：US20080293949A1
公开(公告)日：2008-11-27
申请号：US12078662
申请日：2008-04-02
IPC分类号： C07D277/14
CPC分类号： C07D277/20 , C07D277/24 , C07D277/34
摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。
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公开(公告)号：US07202366B2
公开(公告)日：2007-04-10
申请号：US10808519
申请日：2004-03-25
IPC分类号： A61K31/41 , C07D277/60
CPC分类号： C07D277/20 , C07D277/24 , C07D277/34
摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与之前报道的已知降低瘦蛋白水平的噻唑烷二酮化合物相比，本发明化合物增加瘦素水平并且没有已知的肝脏毒性。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。
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公开(公告)号：US07105552B2
公开(公告)日：2006-09-12
申请号：US09843167
申请日：2001-04-27
IPC分类号： A61K31/41
CPC分类号： C07D277/20 , C07D277/24 , C07D277/34
摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与之前报道的已知降低瘦蛋白水平的噻唑烷二酮化合物相比，本发明化合物增加瘦素水平并且没有已知的肝脏毒性。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。
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公开(公告)号：US06525093B1
公开(公告)日：2003-02-25
申请号：US09436047
申请日：1999-11-08
申请人： Partha Neogi , Bishwajit Nag , Frederick J. Lakner , Debendranath Dey , Satyanarayana Medicherla
发明人： Partha Neogi , Bishwajit Nag , Frederick J. Lakner , Debendranath Dey , Satyanarayana Medicherla
IPC分类号： A01N3710
CPC分类号： C07C69/736
摘要： Compounds are provided that lower blood glucose concentrations, lower serum triglyceride concentrations, lower systolic blood pressure, and increase glucose uptake by adipose tissue, but do not affect the expression of PPAR-&ggr; by adipose tissue.
摘要翻译： 提供化合物，其降低血糖浓度，降低血清甘油三酯浓度，降低收缩压，并增加脂肪组织的葡萄糖摄取，但不影响脂肪组织中PPAR-γ的表达。
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公开(公告)号：US06331633B1
公开(公告)日：2001-12-18
申请号：US09287237
申请日：1999-04-06
IPC分类号： H61K31425
CPC分类号： C07D277/34
摘要： Novel diphenylethylene compounds containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidine compounds, known to lower leptin levels, the present compound increase leptin levels and have no known liver toxicity.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与以前报道的已知降低瘦蛋白水平的噻唑烷化合物相比，本发明化合物增加瘦素水平并且没有已知的肝毒性。
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公开(公告)号：US06245814B1
公开(公告)日：2001-06-12
申请号：US09074925
申请日：1998-05-08
IPC分类号： A61K3119
CPC分类号： C07D277/34
摘要： Novel diphenylethylene and styrenes are provided which are administered orally to decrease blood glucose levels in rats. The glucose tolerance in insulin resistant rats is also shown, as well as lowering of triglyceride levels in serum insulin resistant, hyperinsulinemic and hypertriglycedemic rats. The compounds are orally effective anti-diabetic agents that potentially may reduce abnormality of glucose and lipid metabolism in diabetes.
摘要翻译： 提供新的二苯乙烯和苯乙烯，其口服给药以降低大鼠的血糖水平。 还显示胰岛素抵抗大鼠的葡萄糖耐量，以及降低血清胰岛素抵抗，高胰岛素血症和高胰岛素血症大鼠的甘油三酯水平。 这些化合物是口服有效的抗糖尿病药物，其可能降低糖尿病中葡萄糖和脂质代谢的异常。
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公开(公告)号：US06624197B1
公开(公告)日：2003-09-23
申请号：US09642618
申请日：2000-08-17
IPC分类号： A61K3119
CPC分类号： C07D277/34
摘要： Novel diphenylethylene and styrenes are provided which are administered orally to decrease blood glucose levels in rats. The glucose tolerance in insulin resistant rats is also shown, as well as lowering of triglyceride levels in serum insulin resistant, hyperinsulinemic and hypertriglycedemic rats. The compounds are orally effective anti-diabetic agents that potentially may reduce abnormality of glucose and lipid metabolism in diabetes.
摘要翻译： 提供新的二苯乙烯和苯乙烯，其口服给药以降低大鼠的血糖水平。 还显示胰岛素抵抗大鼠的葡萄糖耐量，以及降低血清胰岛素抵抗，高胰岛素血症和高胰岛素血症大鼠的甘油三酯水平。 这些化合物是口服有效的抗糖尿病药物，其可能降低糖尿病中葡萄糖和脂质代谢的异常。
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公开(公告)号：US20080200521A1
公开(公告)日：2008-08-21
申请号：US12006810
申请日：2008-01-03
申请人： Partha Neogi , Debendranath Dey , Abjiheet Nag , Sujata Neogi , Bishwajit Nag
发明人： Partha Neogi , Debendranath Dey , Abjiheet Nag , Sujata Neogi , Bishwajit Nag
IPC分类号： A61K31/44 , C07C229/28 , A61K31/195 , C07D211/74 , A61P37/00 , A61P3/10 , A61P3/06
CPC分类号： C07C229/36 , C07C259/10 , C07C311/19 , C07D213/643
摘要： Novel hydroxamic acid containing amino acid derivatives are provided that are useful for treatment of inflammation, inflammatory and immunological diseases; lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels; and for treatment or prophylaxis of metabolic disorders.
摘要翻译： 提供了含有氨基酸衍生物的新型异羟肟酸，其可用于治疗炎症，炎症和免疫疾病; 降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平; 并用于治疗或预防代谢紊乱。
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9.发明申请Novel derivatives of amino acids for treatment of obesity and related disorders 审中-公开用于治疗肥胖症和相关疾病的氨基酸的新型衍生物公开(公告)号：US20080175795A1
公开(公告)日：2008-07-24
申请号：US12006803
申请日：2008-01-03
申请人： Partha Neogi , Debendranath Dey , Abjiheet Nag , Bindu Pandey , Preeti Balse , Bishwajit Nag
发明人： Partha Neogi , Debendranath Dey , Abjiheet Nag , Bindu Pandey , Preeti Balse , Bishwajit Nag
IPC分类号： A61K9/12 , C07C233/11 , A61K31/165 , C07D265/30 , A61P37/00 , A61P3/06 , A61P11/00 , A61P3/04 , A61P3/08 , A61K31/5375 , A61K31/495 , C07D295/14
CPC分类号： C07C237/20 , C07C259/06 , C07C311/19 , C07D295/185
摘要： Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as body weight gain, elevated free fatty acid, cholesterol and triglyceride levels and other disorder exacerbated by obesity.
摘要翻译： 提供了可用于治疗肥胖症和免疫疾病等疾病的新型氨基酸衍生物。 该衍生物还可用于降低高血糖病症中的血糖水平和用于治疗相关疾病如体重增加，升高的游离脂肪酸，胆固醇和甘油三酯水平以及由肥胖加剧的其它疾病。
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公开(公告)号：US20070037863A1
公开(公告)日：2007-02-15
申请号：US11429015
申请日：2006-05-04
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Agarwal , Surendra Pandey
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Agarwal , Surendra Pandey
IPC分类号： A61K31/427 , C07D417/02
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06147 , C07K5/06156 , C07K5/06165
摘要： Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
摘要翻译： 新型二肽醚可有效降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平。 二肽醚也可用于治疗和/或预防糖尿病，肥胖，炎症和自身免疫性疾病如多发性硬化和类风湿性关节炎。
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