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    Diphenylethylene compounds
    1.
    发明授权
    Diphenylethylene compounds 失效
    二苯基乙烯化合物

    公开(公告)号：US06245814B1

    公开(公告)日：2001-06-12

    申请号：US09074925

    申请日：1998-05-08

    申请人： Bishwajit Nag ,  Satyanarayana Medicherla ,  Debendranath Dey

    发明人： Bishwajit Nag ,  Satyanarayana Medicherla ,  Debendranath Dey

    IPC分类号： A61K3119

    CPC分类号： C07D277/34

    摘要： Novel diphenylethylene and styrenes are provided which are administered orally to decrease blood glucose levels in rats. The glucose tolerance in insulin resistant rats is also shown, as well as lowering of triglyceride levels in serum insulin resistant, hyperinsulinemic and hypertriglycedemic rats. The compounds are orally effective anti-diabetic agents that potentially may reduce abnormality of glucose and lipid metabolism in diabetes.

    摘要翻译： 提供新的二苯乙烯和苯乙烯，其口服给药以降低大鼠的血糖水平。 还显示胰岛素抵抗大鼠的葡萄糖耐量，以及降低血清胰岛素抵抗，高胰岛素血症和高胰岛素血症大鼠的甘油三酯水平。 这些化合物是口服有效的抗糖尿病药物，其可能降低糖尿病中葡萄糖和脂质代谢的异常。

    Novel heterocyclic analogs of diphenylethylene compounds
    2.
    发明申请
    Novel heterocyclic analogs of diphenylethylene compounds 失效
    二苯基乙烯化合物的新型杂环类似物

    公开(公告)号：US20080293949A1

    公开(公告)日：2008-11-27

    申请号：US12078662

    申请日：2008-04-02

    申请人： Partha Neogi ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Bishwajit Nag ,  Arthur Lee

    发明人： Partha Neogi ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Bishwajit Nag ,  Arthur Lee

    IPC分类号： C07D277/14

    CPC分类号： C07D277/20 ,  C07D277/24 ,  C07D277/34

    摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.

    摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。

    Heterocyclic analogs of diphenylethylene compounds
    3.
    发明授权
    Heterocyclic analogs of diphenylethylene compounds 失效
    二苯基乙烯化合物的杂环类似物

    公开(公告)号：US07202366B2

    公开(公告)日：2007-04-10

    申请号：US10808519

    申请日：2004-03-25

    申请人： Bishwajit Nag ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Partha Neogi

    发明人： Bishwajit Nag ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Partha Neogi

    IPC分类号： A61K31/41 ,  C07D277/60

    CPC分类号： C07D277/20 ,  C07D277/24 ,  C07D277/34

    摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.

    摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与之前报道的已知降低瘦蛋白水平的噻唑烷二酮化合物相比，本发明化合物增加瘦素水平并且没有已知的肝脏毒性。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。

    Diphenylethylene compounds
    4.
    发明授权
    Diphenylethylene compounds 失效
    二苯基乙烯化合物

    公开(公告)号：US06624197B1

    公开(公告)日：2003-09-23

    申请号：US09642618

    申请日：2000-08-17

    申请人： Bishwajit Nag ,  Satyanarayana Medicherla ,  Debendranath Dey

    发明人： Bishwajit Nag ,  Satyanarayana Medicherla ,  Debendranath Dey

    IPC分类号： A61K3119

    CPC分类号： C07D277/34

    摘要： Novel diphenylethylene and styrenes are provided which are administered orally to decrease blood glucose levels in rats. The glucose tolerance in insulin resistant rats is also shown, as well as lowering of triglyceride levels in serum insulin resistant, hyperinsulinemic and hypertriglycedemic rats. The compounds are orally effective anti-diabetic agents that potentially may reduce abnormality of glucose and lipid metabolism in diabetes.

    摘要翻译： 提供新的二苯乙烯和苯乙烯，其口服给药以降低大鼠的血糖水平。 还显示胰岛素抵抗大鼠的葡萄糖耐量，以及降低血清胰岛素抵抗，高胰岛素血症和高胰岛素血症大鼠的甘油三酯水平。 这些化合物是口服有效的抗糖尿病药物，其可能降低糖尿病中葡萄糖和脂质代谢的异常。

    Heterocyclic analogs of diphenylethylene compounds
    5.
    发明授权
    Heterocyclic analogs of diphenylethylene compounds 失效
    二苯基乙烯化合物的杂环类似物

    公开(公告)号：US07105552B2

    公开(公告)日：2006-09-12

    申请号：US09843167

    申请日：2001-04-27

    申请人： Bishwajit Nag ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Partha Neogi

    发明人： Bishwajit Nag ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Partha Neogi

    IPC分类号： A61K31/41

    CPC分类号： C07D277/20 ,  C07D277/24 ,  C07D277/34

    摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.

    摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与之前报道的已知降低瘦蛋白水平的噻唑烷二酮化合物相比，本发明化合物增加瘦素水平并且没有已知的肝脏毒性。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。

    Heterocyclic analogs of diphenylethylene compounds
    7.
    发明授权
    Heterocyclic analogs of diphenylethylene compounds 失效
    二苯基乙烯化合物的杂环类似物

    公开(公告)号：US06331633B1

    公开(公告)日：2001-12-18

    申请号：US09287237

    申请日：1999-04-06

    申请人： Partha Neogi ,  Bishwajit Nag ,  Satyanarayana Medicherla ,  Debendranath Dey

    发明人： Partha Neogi ,  Bishwajit Nag ,  Satyanarayana Medicherla ,  Debendranath Dey

    IPC分类号： H61K31425

    CPC分类号： C07D277/34

    摘要： Novel diphenylethylene compounds containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidine compounds, known to lower leptin levels, the present compound increase leptin levels and have no known liver toxicity.

    摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与以前报道的已知降低瘦蛋白水平的噻唑烷化合物相比，本发明化合物增加瘦素水平并且没有已知的肝毒性。