公开(公告)号：US5049676A

公开(公告)日：1991-09-17

申请号：US530180

申请日：1990-05-30

Applicant: Pascal Metivier ,  Harivelo Rajoharisson

Inventor： Pascal Metivier ,  Harivelo Rajoharisson

IPC: C07C67/307 ,  C07C67/327 ,  C07C69/63 ,  C07D213/63 ,  C07D307/58 ,  C07D333/32

CPC classification number: C07C67/307 ,  C07B2200/07

Abstract: A process for the preparation of optically active esters of 2-chloropropionic acid of the formula: ##STR1## from an optically active lactate of the formula: ##STR2## with inversion of configuration. COOR.sub.1 in formula I and formula II is a hydrolyzable group. The lactate of formula II is brought into contact with SOCl.sub.2, followed by decomposition of the chlorosulfite formed, the process being one in which at least the decomposition stage is carried out in the presence of an ether.

Abstract translation: 一种具有下式的旋光活性乳酸盐的具有下式的下式的2-氯丙酸的光学活性酯的方法：具有反型构型。 式I和式II中的COOR1是可水解基团。 使式II的乳酸与SOCl 2接触，然后分解形成的亚硫酸氢盐，该方法是至少在乙醚存在下进行分解阶段的方法。