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1.发明申请公开(公告)号：US20120244118A1
公开(公告)日：2012-09-27
申请号：US13514855
申请日：2010-12-12
申请人： Pedro Berraondo Lopez , Jessica Fioravanti , Jose Medina Echeverz , Ignacio Javier Melero Bermejo , Maria del Carmen Ochoa Nieto , Francisco de Asis Palazon Garcia , Silvia Bulfone-Paus , Erwin Hans Duitmann
发明人： Pedro Berraondo Lopez , Jessica Fioravanti , Jose Medina Echeverz , Ignacio Javier Melero Bermejo , Maria del Carmen Ochoa Nieto , Francisco de Asis Palazon Garcia , Silvia Bulfone-Paus , Erwin Hans Duitmann
CPC分类号： C07K14/5443 , A61K38/00 , C07K14/7155 , C07K14/775
摘要： The present invention relates to compositions capable of promoting both the innate immune response as well as the adaptive immune response in a subject based on the jointly use of ApoA, interleukin 15 and the Sushi domain of the IL15 receptor alpha chain, as well as to the use of these compositions for the stimulation of the immune response in a patient and to therapeutic methods for the treatment of infectious and neoplastic diseases.
摘要翻译： 本发明涉及基于联合使用ApoA，白细胞介素15和IL15受体α链的寿命结构域，以及对于本发明的本发明，本发明涉及能够促进受试者中的先天免疫应答以及适应性免疫应答的组合物， 使用这些组合物来刺激患者的免疫应答以及用于治疗感染性和肿瘤性疾病的治疗方法。
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2.发明授权Compositions comprising apolipoprotein A polypeptide and interleukin 15, and methods of treatment using the same 有权包含载脂蛋白A多肽和白介素15的组合物，以及使用其的治疗方法公开(公告)号：US08771664B2
公开(公告)日：2014-07-08
申请号：US13514855
申请日：2010-12-10
申请人： Pedro Berraondo Lopez , Jessica Fioravanti , Jose Medina Echeverz , Ignacio Javier Melero Bermejo , Maria del Carmen Ochoa Nieto , Francisco de Asis Palazon Garcia , Silvia Bulfone-Paus , Erwin Hans Duitmann
发明人： Pedro Berraondo Lopez , Jessica Fioravanti , Jose Medina Echeverz , Ignacio Javier Melero Bermejo , Maria del Carmen Ochoa Nieto , Francisco de Asis Palazon Garcia , Silvia Bulfone-Paus , Erwin Hans Duitmann
CPC分类号： C07K14/5443 , A61K38/00 , C07K14/7155 , C07K14/775
摘要： The present invention relates to compositions capable of promoting both the innate immune response as well as the adaptive immune response in a subject based on the jointly use of ApoA, interleukin 15 and the Sushi domain of the IL15 receptor alpha chain, as well as to the use of these compositions for the stimulation of the immune response in a patient and to therapeutic methods for the treatment of infectious and neoplastic diseases.
摘要翻译： 本发明涉及基于联合使用ApoA，白细胞介素15和IL15受体α链的寿命结构域，以及对于本发明的本发明，本发明涉及能够促进受试者中的先天免疫应答以及适应性免疫应答的组合物， 使用这些组合物来刺激患者的免疫应答以及用于治疗感染性和肿瘤性疾病的治疗方法。
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公开(公告)号：US20110293557A1
公开(公告)日：2011-12-01
申请号：US12997829
申请日：2009-06-12
IPC分类号： A61K38/20 , C07K14/555 , C07H21/04 , C12N15/63 , C12N5/00 , A61P1/16 , A61K38/00 , A61P25/16 , A61P35/00 , A61P17/00 , A61P31/04 , A61P33/00 , A61P19/02 , A61K39/00 , C07K14/775
CPC分类号： A61K38/1709 , A61K45/06 , A61K47/64 , C07K14/47 , C07K14/5434 , C07K14/56 , C07K14/775
摘要： The invention relates to a conjugate that comprises an Apo A molecule or a functionally equivalent variant thereof and a compound of therapeutic interest wherein both components are covalently coupled as well as to the use of said conjugates in therapy for the specific targeting of said compounds to those tissues showing specific binding sites for the ApoA molecule.
摘要翻译： 本发明涉及包含Apo A分子或其功能等同变体的缀合物和治疗感兴趣的化合物，其中两种组分共价偶联，以及所述缀合物在治疗中用于所述化合物对这些化合物的特异性靶向的用途 显示ApoA分子特异性结合位点的组织。
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