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公开(公告)号：US20070049526A1
公开(公告)日：2007-03-01
申请号：US11548805
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： A61K38/17
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
摘要翻译： 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了用Zven1和Zven2多肽治疗肠蠕动障碍和改善胃肠功能的方法。
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公开(公告)号：US20070065403A1
公开(公告)日：2007-03-22
申请号：US11548810
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： A61K38/20
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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公开(公告)号：US20070087414A1
公开(公告)日：2007-04-19
申请号：US11548826
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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公开(公告)号：US20070078259A1
公开(公告)日：2007-04-05
申请号：US11548830
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： C07K14/715
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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公开(公告)号：US20070065405A1
公开(公告)日：2007-03-22
申请号：US11548824
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： A61K38/54
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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公开(公告)号：US20070065404A1
公开(公告)日：2007-03-22
申请号：US11548819
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
摘要翻译： 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了用Zven1和Zven2多肽治疗肠蠕动障碍和改善胃肠功能的方法。
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公开(公告)号：US20070048258A1
公开(公告)日：2007-03-01
申请号：US11548814
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： A61K38/19
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
摘要翻译： 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了用Zven1和Zven2多肽治疗肠蠕动障碍和改善胃肠功能的方法。
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公开(公告)号：US20060258586A1
公开(公告)日：2006-11-16
申请号：US11418803
申请日：2006-05-05
申请人： Paul Sheppard , Stephen Jaspers , Michael Stamm , Anitra Wolf , Jacob Kennedy
发明人： Paul Sheppard , Stephen Jaspers , Michael Stamm , Anitra Wolf , Jacob Kennedy
IPC分类号： C07K14/705 , A61K38/17
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/523
摘要： The present invention provides methods of using Zsig98 polypeptides for treating intestinal motility disorders and improving gastrointestinal function, nutritient absorption, metabolism, and diabetes with Zsig98 polypeptides. The invention also provides methods for producing Zsig98 polynucleotides, polypeptides and antibodies.
摘要翻译： 本发明提供使用Zsig98多肽治疗肠蠕动障碍并通过Zsig98多肽改善胃肠功能，营养吸收，代谢和糖尿病的方法。 本发明还提供了生产Zsig98多核苷酸，多肽和抗体的方法。
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公开(公告)号：US20070092912A1
公开(公告)日：2007-04-26
申请号：US11551008
申请日：2006-10-19
申请人： Penny Thompson , Paul Sheppard
发明人： Penny Thompson , Paul Sheppard
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.
摘要翻译： 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了使用Zven1和Zven2的拮抗剂治疗肠道炎症的方法。
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公开(公告)号：US20070048840A1
公开(公告)日：2007-03-01
申请号：US11549222
申请日：2006-10-13
申请人： Paul Sheppard , Paul Bishop , Theodore Whitmore , Penny Thompson
发明人： Paul Sheppard , Paul Bishop , Theodore Whitmore , Penny Thompson
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1 - 3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.
摘要翻译： 本发明提供新的用途，称为“Zven”的新家族人类蛋白质的两个成员，作为刺激胃肠收缩力，胃排空，肠道运输和治疗胃轻瘫的药物。位于人染色体3p21.1中的Zven1基因 3p14.3，表达于睾丸组织和外周血淋巴细胞。 本发明还提供了使用抗体检测蛋白质与抗体的方法以及使用多核苷酸检测Zven RNA的存在的方法。
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